Genetic variability in adult bone density among inbred strains of mice - PubMed (original) (raw)
Genetic variability in adult bone density among inbred strains of mice
W G Beamer et al. Bone. 1996 May.
Abstract
More than 70% of the variability in human bone density has been attributed to genetic factors as a result of studies with twins, osteoporotic families, and individuals with rare heritable bone disorders. We have applied the Stratec XCT 960M pQCT, specifically modified for small skeletal specimens, to analyses of bones from 11 inbred strains (AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, NZB/B1NJ, SM/J, SJL/BmJ, SWR/BmJ, and 129/J) of female mice to determine the extent of heritable differences in peak bone density, pQCT scans were taken of femurs from (a) 12-month-old inbred strain females and (b) a subset of four strains (C3H/HeJ, DBA/2J, BALB/cByJ, C57BL/6J) at 2, 4, and 8 months. In addition, pQCT scans were also obtained from L5-L6 vertebrae and proximal phalanges from the same subset of four inbred strains at 12 months of age. Comparison of bone parameters among inbred strains revealed significant differences at each of the three sites investigated. Femoral and phalangeal bones differed among strains with respect to total and cortical density, mineral, and volume. Only cortical bone parameters were significantly different among strains at the vertebral site. With respect to strain differences, the highest value for any given bone parameter was found in the C3H/HeJ strain, whereas C57BL/6J values were absolutely, or statistically, the lowest. Similarly, with respect to bone sites, cortical bone density was significantly correlated among strains. On the other hand, we found that none of the femur, vertebral, or phalangeal parameters correlated with body weight, even though body weight varied by 86% among those inbred strains. The developmental studies of femurs conducted at 2, 4, and 8 months of age with C3H/HeJ, DBA/2J, BALB/cByJ, and C57BL/6J females showed differences in total density among strains at 2 months and thereafter. Adult peak bone density was typically achieved by 4 months, whereas femurs continued to lengthen for 4 to 8 months thereafter. We conclude that (1) major genetic effects on femoral, vertebral, and phalangeal bone density are detectable among inbred strains of mice; (2) cortical bone density shares common genetic regulation at the three measured sites; and (3) within the femur, genes that regulate length and density are different.
Similar articles
- Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice.
Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. Beamer WG, et al. J Bone Miner Res. 2001 Jul;16(7):1195-206. doi: 10.1359/jbmr.2001.16.7.1195. J Bone Miner Res. 2001. PMID: 11450694 - Ovariectomy-induced bone loss varies among inbred strains of mice.
Bouxsein ML, Myers KS, Shultz KL, Donahue LR, Rosen CJ, Beamer WG. Bouxsein ML, et al. J Bone Miner Res. 2005 Jul;20(7):1085-92. doi: 10.1359/JBMR.050307. Epub 2005 Mar 7. J Bone Miner Res. 2005. PMID: 15940361 - Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice.
Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Müller R, Beamer WG. Bouxsein ML, et al. J Bone Miner Res. 2004 Apr;19(4):587-99. doi: 10.1359/JBMR.0301255. Epub 2003 Dec 22. J Bone Miner Res. 2004. PMID: 15005846 - Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology.
Judex S, Garman R, Squire M, Donahue LR, Rubin C. Judex S, et al. J Bone Miner Res. 2004 Apr;19(4):600-6. doi: 10.1359/JBMR.040101. Epub 2004 Jan 5. J Bone Miner Res. 2004. PMID: 15005847 - Genetic heterogeneity of lipoproteins in inbred strains of mice: analysis by gel-permeation chromatography.
Jiao S, Cole TG, Kitchens RT, Pfleger B, Schonfeld G. Jiao S, et al. Metabolism. 1990 Feb;39(2):155-60. doi: 10.1016/0026-0495(90)90069-o. Metabolism. 1990. PMID: 2299988
Cited by
- Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response.
Jou V, Peña SM, Lehoczky JA. Jou V, et al. bioRxiv [Preprint]. 2024 Jun 15:2024.06.12.598713. doi: 10.1101/2024.06.12.598713. bioRxiv. 2024. PMID: 38915675 Free PMC article. Preprint. - Multi-scale cortical bone traits vary in females and males from two mouse models of genetic diversity.
Migotsky N, Kumar S, Shuster JT, Coulombe JC, Senwar B, Gestos AA, Farber CR, Ferguson VL, Silva MJ. Migotsky N, et al. JBMR Plus. 2024 Feb 21;8(5):ziae019. doi: 10.1093/jbmrpl/ziae019. eCollection 2024 May. JBMR Plus. 2024. PMID: 38634075 Free PMC article. - CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair.
Hankenson K, Zondervan R, Capobianco C, Jenkins D, Reicha J, Frederick L, Lam C, Isenberg J, Ahn J, Marcucio RS. Hankenson K, et al. Res Sq [Preprint]. 2024 Mar 19:rs.3.rs-4022423. doi: 10.21203/rs.3.rs-4022423/v1. Res Sq. 2024. PMID: 38562718 Free PMC article. Preprint. - Sex-specific effects of Fat-1 transgene on bone material properties, size, and shape in mice.
Bermudez B, Brown KC, Vahidi G, Ferreira Ruble AC, Heveran CM, Ackert-Bicknell CL, Sherk VD. Bermudez B, et al. JBMR Plus. 2024 Jan 10;8(4):ziad011. doi: 10.1093/jbmrpl/ziad011. eCollection 2024 Apr. JBMR Plus. 2024. PMID: 38523667 Free PMC article. - Rapamycin does not alter bone microarchitecture or material properties quality in young-adult and aged female C57BL/6 mice.
Devine CC, Brown KC, Paton KO, Heveran CM, Martin SA. Devine CC, et al. JBMR Plus. 2024 Jan 10;8(2):ziae001. doi: 10.1093/jbmrpl/ziae001. eCollection 2024 Feb. JBMR Plus. 2024. PMID: 38505525 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases