Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils - PubMed (original) (raw)
. 1996 Aug 22;382(6593):716-9.
doi: 10.1038/382716a0.
Affiliations
- PMID: 8751442
- DOI: 10.1038/382716a0
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils
J El Khoury et al. Nature. 1996.
Abstract
A pathological hallmark of Alzheimer's disease is the senile plaque, containing beta-amyloid fibrils, microglia and astrocytes. Beta-amyloid fibrils exert a cytotoxic effect on neurons, and stimulate microglia to produce neurotoxins, such as reactive oxygen species. Mononuclear phagocytes, including microglia, express scavenger receptors that mediate endocytosis of oxidized low-density lipoproteins, and adhesion to glucose-modified extra-cellular matrix proteins. Here we report that class A scavenger receptors mediate adhesion of rodent microglia and human monocytes to beta-amyloid fibril-coated surfaces leading to secretion of reactive oxygen species and cell immobilization. Thus, class A scavenger receptors are potential therapeutic targets in Alzheimer's disease.
Comment in
- Alzheimer's disease. Amyloid ox-tox transducers.
Mattson MP, Rydel RE. Mattson MP, et al. Nature. 1996 Aug 22;382(6593):674-5. doi: 10.1038/382674a0. Nature. 1996. PMID: 8751434 No abstract available.
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