Two different areas within the primary motor cortex of man - PubMed (original) (raw)
. 1996 Aug 29;382(6594):805-7.
doi: 10.1038/382805a0.
Affiliations
- PMID: 8752272
- DOI: 10.1038/382805a0
Two different areas within the primary motor cortex of man
S Geyer et al. Nature. 1996.
Abstract
The primary motor area (M1) of mammals has long been considered to be structurally and functionally homogeneous. This area corresponds to Brodmann's cytoarchitectural area 4. A few reports showing that arm and hand are doubly represented in M1 of macaque monkeys and perhaps man, and that each subarea has separate connections from somatosensory areas, have, with a few exceptions, gone largely unnoticed. Here we show that area 4 in man can be subdivided into areas '4 anterior' (4a) and '4 posterior' (4p) on the basis of both quantitative cytoarchitecture and quantitative distributions of transmitter-binding sites. We also show by positron emission tomography that two representations of the fingers exist, one in area 4a and one in area 4p. Roughness discrimination activated area 4p significantly more than a control condition of self-generated movements. We therefore suggest that the primary motor area is subdivided on the basis of anatomy, neurochemistry and function.
Similar articles
- Participation of primary motor cortex area 4a in complex sensory processing: 3.0-T fMRI study.
Terumitsu M, Ikeda K, Kwee IL, Nakada T. Terumitsu M, et al. Neuroreport. 2009 May 6;20(7):679-83. doi: 10.1097/WNR.0b013e32832a1820. Neuroreport. 2009. PMID: 19339906 - Imagery of voluntary movement of fingers, toes, and tongue activates corresponding body-part-specific motor representations.
Ehrsson HH, Geyer S, Naito E. Ehrsson HH, et al. J Neurophysiol. 2003 Nov;90(5):3304-16. doi: 10.1152/jn.01113.2002. J Neurophysiol. 2003. PMID: 14615433 - The primary motor and premotor areas of the human cerebral cortex.
Chouinard PA, Paus T. Chouinard PA, et al. Neuroscientist. 2006 Apr;12(2):143-52. doi: 10.1177/1073858405284255. Neuroscientist. 2006. PMID: 16514011 Review. - On somatotopic representation centers for finger movements in human primary motor cortex and supplementary motor area.
Indovina I, Sanes JN. Indovina I, et al. Neuroimage. 2001 Jun;13(6 Pt 1):1027-34. doi: 10.1006/nimg.2001.0776. Neuroimage. 2001. PMID: 11352608 - [Plasticity of motor maps in primates: recent advances and therapeutical perspectives].
Vandermeeren Y, Bastings E, Good D, Rouiller E, Olivier E. Vandermeeren Y, et al. Rev Neurol (Paris). 2003 Mar;159(3):259-75. Rev Neurol (Paris). 2003. PMID: 12703042 Review. French.
Cited by
- Left motor cortex contributes to auditory phonological discrimination.
Perron M, Ross B, Alain C. Perron M, et al. Cereb Cortex. 2024 Sep 3;34(9):bhae369. doi: 10.1093/cercor/bhae369. Cereb Cortex. 2024. PMID: 39329356 Free PMC article. - Double dissociation of visuomotor interaction mediated by visual feedback during continuous de novo motor learning.
Kim J, Park S, Yoo K, Kim S. Kim J, et al. Commun Biol. 2024 Sep 11;7(1):1117. doi: 10.1038/s42003-024-06808-z. Commun Biol. 2024. PMID: 39261584 Free PMC article. - Connectivity defines the distinctive anatomy and function of the hand-knob area.
Beyh A, Howells H, Giampiccolo D, Cancemi D, De Santiago Requejo F, Citro S, Keeble H, Lavrador JP, Bhangoo R, Ashkan K, Dell'Acqua F, Catani M, Vergani F. Beyh A, et al. Brain Commun. 2024 Aug 13;6(5):fcae261. doi: 10.1093/braincomms/fcae261. eCollection 2024. Brain Commun. 2024. PMID: 39239149 Free PMC article. - Motor somatotopy impacts imagery strategy success in human intracortical brain-computer interfaces.
Kunigk NG, Schone HR, Gontier C, Hockeimer W, Tortolani AF, Hatsopoulos NG, Downey JE, Chase SM, Boninger ML, Dekleva BD, Collinger JL. Kunigk NG, et al. medRxiv [Preprint]. 2024 Aug 3:2024.08.01.24311180. doi: 10.1101/2024.08.01.24311180. medRxiv. 2024. PMID: 39132484 Free PMC article. Preprint. - The excitability of ipsilateral motor evoked potentials is not task-specific and spatially distinct from the contralateral motor hotspot.
Seusing N, Strauss S, Fleischmann R, Nafz C, Groppa S, Muthuraman M, Ding H, Byblow WD, Lotze M, Grothe M. Seusing N, et al. Exp Brain Res. 2024 Aug;242(8):1851-1859. doi: 10.1007/s00221-024-06851-6. Epub 2024 Jun 6. Exp Brain Res. 2024. PMID: 38842754 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources