Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor - PubMed (original) (raw)
. 1996 Aug 5;225(1):69-74.
doi: 10.1006/bbrc.1996.1132.
Affiliations
- PMID: 8769096
- DOI: 10.1006/bbrc.1996.1132
Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor
K Hotta et al. Biochem Biophys Res Commun. 1996.
Abstract
The Rho family small G proteins are implicated in various cell functions, such as cell morphological change, cell motility, and cytokinesis. However, their modes of action in regulating these cell functions remain to be clarified. In the present study, we have isolated a cDNA encoding a protein which interacts with the GTP-bound form, but not with the GDP-bound form, of the Rho family members, including RhoA, Racl, and Cdc42, by the yeast two-hybrid method. This protein is kinectin, known to be a vesicle membrane anchoring protein of kinesin, which is an ATPase motor transporting vesicles along microtubules.
Similar articles
- Rho family members: activators of MAP kinase cascades.
Vojtek AB, Cooper JA. Vojtek AB, et al. Cell. 1995 Aug 25;82(4):527-9. doi: 10.1016/0092-8674(95)90023-3. Cell. 1995. PMID: 7664330 Review. No abstract available. - Kinectin is a key effector of RhoG microtubule-dependent cellular activity.
Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P. Vignal E, et al. Mol Cell Biol. 2001 Dec;21(23):8022-34. doi: 10.1128/MCB.21.23.8022-8034.2001. Mol Cell Biol. 2001. PMID: 11689693 Free PMC article. - C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.
Gosser YQ, Nomanbhoy TK, Aghazadeh B, Manor D, Combs C, Cerione RA, Rosen MK. Gosser YQ, et al. Nature. 1997 Jun 19;387(6635):814-9. doi: 10.1038/42961. Nature. 1997. PMID: 9194563 - Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.
Kohno H, Tanaka K, Mino A, Umikawa M, Imamura H, Fujiwara T, Fujita Y, Hotta K, Qadota H, Watanabe T, Ohya Y, Takai Y. Kohno H, et al. EMBO J. 1996 Nov 15;15(22):6060-8. EMBO J. 1996. PMID: 8947028 Free PMC article. - Biochemical analyses of the Wrch atypical Rho family GTPases.
Shutes A, Berzat AC, Chenette EJ, Cox AD, Der CJ. Shutes A, et al. Methods Enzymol. 2006;406:11-26. doi: 10.1016/S0076-6879(06)06002-2. Methods Enzymol. 2006. PMID: 16472646 Review.
Cited by
- CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms.
Fang WB, Jokar I, Zou A, Lambert D, Dendukuri P, Cheng N. Fang WB, et al. J Biol Chem. 2012 Oct 19;287(43):36593-608. doi: 10.1074/jbc.M112.365999. Epub 2012 Aug 27. J Biol Chem. 2012. PMID: 22927430 Free PMC article. - The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.
Piddini E, Schmid JA, de Martin R, Dotti CG. Piddini E, et al. EMBO J. 2001 Aug 1;20(15):4076-87. doi: 10.1093/emboj/20.15.4076. EMBO J. 2001. PMID: 11483511 Free PMC article. - Rho GTPases and their effector proteins.
Bishop AL, Hall A. Bishop AL, et al. Biochem J. 2000 Jun 1;348 Pt 2(Pt 2):241-55. Biochem J. 2000. PMID: 10816416 Free PMC article. Review. - Modulation of HIV-1 replication by a novel RhoA effector activity.
Wang L, Zhang H, Solski PA, Hart MJ, Der CJ, Su L. Wang L, et al. J Immunol. 2000 May 15;164(10):5369-74. doi: 10.4049/jimmunol.164.10.5369. J Immunol. 2000. PMID: 10799900 Free PMC article. - RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs.
Gauthier-Rouvière C, Vignal E, Mériane M, Roux P, Montcourier P, Fort P. Gauthier-Rouvière C, et al. Mol Biol Cell. 1998 Jun;9(6):1379-94. doi: 10.1091/mbc.9.6.1379. Mol Biol Cell. 1998. PMID: 9614181 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous