Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats - PubMed (original) (raw)

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats

H C Rath et al. J Clin Invest. 1996.

Abstract

Genetic and environmental factors are important in the pathogenesis of clinical and experimental chronic intestinal inflammation. We investigated the influence of normal luminal bacteria and several groups of selected bacterial strains on spontaneous gastrointestinal and systemic inflammation in HLA-B27 transgenic rats. Rats maintained germfree for 3-9 mo were compared with littermates conventionalized with specific pathogen-free bacteria. Subsequently, germfree transgenic rats were colonized with groups of five to eight bacteria that were either facultative or strictly anaerobic. Transgenic germfree rats had no gastroduodenitis, colitis, or arthritis, but developed epididymitis and dermatitis to the same degree as conventionalized rats. Colonic proinflammatory cytokine expression was increased in transgenic conventionalized rats but was undetectable in germfree and nontransgenic rats. Colitis progressively increased over the first 4 wk of bacterial exposure, then plateaued. Only transgenic rats colonized with defined bacterial cocktails which contained Bacteroides spp. had colitis and gastritis. Normal luminal bacteria predictably and uniformly induce chronic colonic, gastric and systemic inflammation in B27 transgenic F344 rats, but all bacterial species do not have equal activities.

PubMed Disclaimer

Similar articles

• Role of commensal bacteria in chronic experimental colitis: lessons from the HLA-B27 transgenic rat.
  Rath HC. Rath HC. Pathobiology. 2002-2003;70(3):131-8. doi: 10.1159/000068144. Pathobiology. 2002. PMID: 12571416 Review.
• Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli.
  Rath HC, Wilson KH, Sartor RB. Rath HC, et al. Infect Immun. 1999 Jun;67(6):2969-74. doi: 10.1128/IAI.67.6.2969-2974.1999. Infect Immun. 1999. PMID: 10338507 Free PMC article.
• Sequential changes in luminal microflora and mucosal cytokine expression during developing of colitis in HLA-B27/beta2-microglobulin transgenic rats.
  Hata K, Andoh A, Sato H, Araki Y, Tanaka M, Tsujikawa T, Fujiyama Y, Bamba T. Hata K, et al. Scand J Gastroenterol. 2001 Nov;36(11):1185-92. doi: 10.1080/00365520152584824. Scand J Gastroenterol. 2001. PMID: 11686219
• Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats.
  Rath HC, Ikeda JS, Linde HJ, Schölmerich J, Wilson KH, Sartor RB. Rath HC, et al. Gastroenterology. 1999 Feb;116(2):310-9. doi: 10.1016/s0016-5085(99)70127-7. Gastroenterology. 1999. PMID: 9922311
• Colitis in HLA-B27/beta 2 microglobulin transgenic rats.
  Sartor RB. Sartor RB. Int Rev Immunol. 2000;19(1):39-50. doi: 10.3109/08830180009048388. Int Rev Immunol. 2000. PMID: 10723676 Review.

Cited by

• Alterations in Gut Microbiota and Upregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation.
  Liu GH, Zhuo XC, Huang YH, Liu HM, Wu RC, Kuo CJ, Chen NH, Chuang LP, Lin SW, Chen YL, Yang HY, Lee TY. Liu GH, et al. Biology (Basel). 2022 Jun 25;11(7):962. doi: 10.3390/biology11070962. Biology (Basel). 2022. PMID: 36101343 Free PMC article.
• Do probiotics have a therapeutic role in gastroenterology?
  Limdi JK, O'Neill C, McLaughlin J. Limdi JK, et al. World J Gastroenterol. 2006 Sep 14;12(34):5447-57. doi: 10.3748/wjg.v12.i34.5447. World J Gastroenterol. 2006. PMID: 17006980 Free PMC article. Review.
• Peptidomics analysis of plasma in patients with ankylosing spondylitis.
  Zhang GN, Xu YJ, Jin L. Zhang GN, et al. Front Immunol. 2023 Jan 31;14:1104351. doi: 10.3389/fimmu.2023.1104351. eCollection 2023. Front Immunol. 2023. PMID: 36798127 Free PMC article.
• Luminal bacterial antigen-specific CD4+ T-cell responses in HLA-B27 transgenic rats with chronic colitis are mediated by both major histocompatibility class II and HLA-B27 molecules.
  Qian BF, Tonkonogy SL, Balfour Sartor R. Qian BF, et al. Immunology. 2006 Mar;117(3):319-28. doi: 10.1111/j.1365-2567.2005.02303.x. Immunology. 2006. PMID: 16476051 Free PMC article.
• Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
  Bene L, Füst G, Huszti Z, Hernádi Z, Fekete B, Mészáros M, Veres A, Kovács A, Miklós K, Singh M, Romics L, Prohászka Z. Bene L, et al. Dig Dis Sci. 2002 Jul;47(7):1432-7. doi: 10.1023/a:1015882127674. Dig Dis Sci. 2002. PMID: 12141797

References

1. 1. Infect Immun. 1988 Aug;56(8):2101-8 - PubMed
2. 1. Arthritis Rheum. 1985 Dec;28(12):1402-11 - PubMed
3. 1. Scand J Gastroenterol. 1988 Nov;23(9):1125-31 - PubMed
4. 1. J Biochem. 1989 Mar;105(3):351-7 - PubMed
5. 1. J Rheumatol. 1989 Aug;16(8):1061-8 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • American Society for Clinical Investigation
  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal