Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1 - PubMed (original) (raw)

. 1996 Mar;148(3):855-64.

Affiliations

Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1

M L Rand et al. Am J Pathol. 1996 Mar.

Abstract

Leukocytes express chemokine receptors that, upon ligand recognition, are believed to activate and induce the directed migration of these cells from the vasculature to sites of tissue injury. Previous investigations of human and animal inflammatory tissue have revealed that expression of chemokines can be increased in association with leukocyte infiltration. Monocyte chemotactic protein-1 (MCP-1) mediates monocyte chemotaxis in vitro and migration of monocytes to inflammatory sites in vivo. More recently T cell chemotaxis to MCP-1 has been observed in vitro, but the contribution of this protein to T cell migration in vivo and to lymphocyte-mediated inflammation has not been determined. In this report, we show that using a rat model of cutaneous delayed hypersensitivity, MCP-1 expression correlates spatially and kinetically with T cell and monocyte recruitment and that antibodies directed to MCP-1 when administered therapeutically to animals undergoing delayed hypersensitivity can almost completely abolish T cell migration and inflammatory sequelae. Moreover the concentration of antibody needed to inhibit T cell trafficking to inflammatory sites is almost on order of magnitude lower than that needed to impede monocyte recruitment. Therefore, MCP-1 is functionally relevant in the genesis of delayed hypersensitivity and may be a useful therapeutic target for diseases mediated in part by T lymphocytes.

PubMed Disclaimer

References

    1. J Exp Med. 1990 Jun 1;171(6):2177-82 - PubMed
    1. J Exp Med. 1995 Jun 1;181(6):2153-9 - PubMed
    1. Nature. 1990 Aug 2;346(6283):425-34 - PubMed
    1. Nature. 1990 Oct 18;347(6294):669-71 - PubMed
    1. J Immunol. 1991 Feb 15;146(4):1192-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources