The dosage compensation system of Drosophila is co-opted by newly evolved X chromosomes - PubMed (original) (raw)
. 1996 Sep 12;383(6596):160-3.
doi: 10.1038/383160a0.
Affiliations
- PMID: 8774878
- DOI: 10.1038/383160a0
The dosage compensation system of Drosophila is co-opted by newly evolved X chromosomes
I Marín et al. Nature. 1996.
Abstract
In species where males and females differ in number of sex chromosomes, the expression of sex-linked genes is equalized by a process known as dosage compensation. In Drosophila melanogaster, dosage compensation is mediated by the binding of the products of the male-specific lethal (msl) genes to the single male X chromosome. Here we report that the sex- and chromosome-specific binding of three of the msl proteins (MSLs) occurs in other drosophilid species, spanning four genera. Moreover, we show that MSL binding correlates with the evolution of the sex chromosomes: in species that have acquired a second X chromosome arm because of an X-autosome translocation, we observe binding of the MSLs to the 'new' (previously autosomal) arm of the X chromosome, only when its homologue has degenerated. Moreover, in Drosophila miranda, a Y-autosome translocation has produced a new X chromosome (called neo-X), only some regions of which are dosage compensated. In this neo-X chromosome, the pattern of MSL binding correlates with the known pattern of dosage compensation.
Similar articles
- X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila.
Legube G, McWeeney SK, Lercher MJ, Akhtar A. Legube G, et al. Genes Dev. 2006 Apr 1;20(7):871-83. doi: 10.1101/gad.377506. Epub 2006 Mar 17. Genes Dev. 2006. PMID: 16547175 Free PMC article. - Evolution of sex chromosomes: dosage compensation of the Lcp1-4 gene cluster on the evolving neo-X chromosome in Drosophila miranda.
Steinemann S, Steinemann M. Steinemann S, et al. Insect Mol Biol. 2007 Apr;16(2):167-74. doi: 10.1111/j.1365-2583.2006.00711.x. Insect Mol Biol. 2007. PMID: 17352708 - MSL complex associates with clusters of actively transcribed genes along the Drosophila male X chromosome.
Larschan E, Alekseyenko AA, Lai WR, Park PJ, Kuroda MI. Larschan E, et al. Cold Spring Harb Symp Quant Biol. 2006;71:385-94. doi: 10.1101/sqb.2006.71.026. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381321 - The evolution of dosage-compensation mechanisms.
Marín I, Siegal ML, Baker BS. Marín I, et al. Bioessays. 2000 Dec;22(12):1106-14. doi: 10.1002/1521-1878(200012)22:12<1106::AID-BIES8>3.0.CO;2-W. Bioessays. 2000. PMID: 11084626 Review. - Path to equality strewn with roX.
Kelley RL. Kelley RL. Dev Biol. 2004 May 1;269(1):18-25. doi: 10.1016/j.ydbio.2004.01.039. Dev Biol. 2004. PMID: 15081354 Review.
Cited by
- Transposon wave remodeled the epigenomic landscape in the rapid evolution of X-Chromosome dosage compensation.
Metzger DCH, Porter I, Mobley B, Sandkam BA, Fong LJM, Anderson AP, Mank JE. Metzger DCH, et al. Genome Res. 2023 Dec 1;33(11):1917-1931. doi: 10.1101/gr.278127.123. Genome Res. 2023. PMID: 37989601 Free PMC article. - The Effect of Chromosomes on Courtship Behavior in Sibling Species of the Drosophila virilis Group.
Belkina EG, Seleznev DG, Sorokina SY, Kulikov AM, Lazebny OE. Belkina EG, et al. Insects. 2023 Jul 5;14(7):609. doi: 10.3390/insects14070609. Insects. 2023. PMID: 37504615 Free PMC article. - Recent Evolution of a Maternally Acting Sex-Determining Supergene in a Fly with Single-Sex Broods.
Baird RB, Urban JM, Mongue AJ, Jaron KS, Hodson CN, Grewoldt M, Martin SH, Ross L. Baird RB, et al. Mol Biol Evol. 2023 Jul 5;40(7):msad148. doi: 10.1093/molbev/msad148. Mol Biol Evol. 2023. PMID: 37352554 Free PMC article. - X chromosomes show relaxed selection and complete somatic dosage compensation across Timema stick insect species.
Parker DJ, Jaron KS, Dumas Z, Robinson-Rechavi M, Schwander T. Parker DJ, et al. J Evol Biol. 2022 Dec;35(12):1734-1750. doi: 10.1111/jeb.14075. Epub 2022 Aug 7. J Evol Biol. 2022. PMID: 35933721 Free PMC article. - Rapid Evolution of Complete Dosage Compensation in Poecilia.
Metzger DCH, Sandkam BA, Darolti I, Mank JE. Metzger DCH, et al. Genome Biol Evol. 2021 Jul 6;13(7):evab155. doi: 10.1093/gbe/evab155. Genome Biol Evol. 2021. PMID: 34240180 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases