The role of Na-Ca exchange current in the cardiac action potential - PubMed (original) (raw)
Affiliations
- PMID: 8776405
Review
The role of Na-Ca exchange current in the cardiac action potential
N C Janvier et al. Cardiovasc Res. 1996 Jul.
Abstract
Since 1981, when Mullins published his provocative book proposing that the Na-Ca exchanger is electrogenic, it has been shown, first by computer simulation by Noble and later by experiment by various investigators, that inward iNaCa triggered by the Ca2+ transient is responsible for the low plateau of the atrial action potential and contributes to the high plateau of the ventricular action potential. Reduction or complete block of inward iNaCa by buffering intracellular Ca2+ with EGTA or BAPTA, by blocking SR Ca2+ release or by substituting extracellular Na+ with Li+ can result in a shortening of the action potential. The effect of block of outward iNaCa or complete block of both inward and outward iNaCa on the action potential has not been investigated experimentally, because of the lack of a suitable blocker, and remains a goal for the future. An increase in the intracellular Na+ concentration (after the application of cardiac glycoside or an increase in heart rate) or an increase in extracellular Ca2+ are believed to lead to an outward shift in iNaCa at plateau potentials and a shortening of the action potential. Changes in the Ca2+ transient are expected to result in changes in inward iNaCa and thus the action potential. This may explain the shortening of the premature action potential as well as the prolongation of the action potential when a muscle is allowed to shorten during the action potential. Inward iNaCa may play an important role in both normal and abnormal pacemaker activity in the heart.
Similar articles
- The role of inward Na(+)-Ca2+ exchange current in the ferret ventricular action potential.
Janvier NC, Harrison SM, Boyett MR. Janvier NC, et al. J Physiol. 1997 Feb 1;498 ( Pt 3)(Pt 3):611-25. doi: 10.1113/jphysiol.1997.sp021887. J Physiol. 1997. PMID: 9051574 Free PMC article. - Role of Na-Ca exchange in the action potential changes caused by drive in cardiac myocytes exposed to different Ca2+ loads.
Liu QY, Vassalle M. Liu QY, et al. Can J Physiol Pharmacol. 1999 Jun;77(6):383-97. Can J Physiol Pharmacol. 1999. PMID: 10537224 - Modulation of Na+,Ca2+ exchange current by EGTA calcium buffering in giant cardiac membrane patches.
Kabakov AY, Hilgemann DW. Kabakov AY, et al. Biochim Biophys Acta. 1995 Dec 13;1240(2):142-8. doi: 10.1016/0005-2736(95)00202-2. Biochim Biophys Acta. 1995. PMID: 8541285 - Ionic basis of excitation mechanism in cardiac muscle.
Coraboeuf E. Coraboeuf E. Recent Adv Stud Cardiac Struct Metab. 1976 May 26-29;11:11-8. Recent Adv Stud Cardiac Struct Metab. 1976. PMID: 801571 Review. - [Oscillatory changes in the intracellular Ca2+ concentration in cardiac muscles].
Komukai K, Tanaka E, Kurihara S. Komukai K, et al. Nihon Rinsho. 1996 Aug;54(8):2045-9. Nihon Rinsho. 1996. PMID: 8810775 Review. Japanese.
Cited by
- Scn1b expression in the adult mouse heart modulates Na+ influx in myocytes and reveals a mechanistic link between Na+ entry and diastolic function.
Cervantes DO, Pizzo E, Ketkar H, Parambath SP, Tang S, Cianflone E, Cannata A, Vinukonda G, Jain S, Jacobson JT, Rota M. Cervantes DO, et al. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H975-H993. doi: 10.1152/ajpheart.00465.2021. Epub 2022 Apr 8. Am J Physiol Heart Circ Physiol. 2022. PMID: 35394857 Free PMC article. - Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents.
Horváth B, Hézső T, Kiss D, Kistamás K, Magyar J, Nánási PP, Bányász T. Horváth B, et al. Front Pharmacol. 2020 Apr 20;11:413. doi: 10.3389/fphar.2020.00413. eCollection 2020. Front Pharmacol. 2020. PMID: 32372952 Free PMC article. Review. - Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model.
Fernandez-Chas M, Curtis MJ, Niederer SA. Fernandez-Chas M, et al. Br J Pharmacol. 2018 Mar;175(5):763-781. doi: 10.1111/bph.14104. Epub 2018 Jan 23. Br J Pharmacol. 2018. PMID: 29161764 Free PMC article. - Nicorandil stimulates a Na⁺/Ca²⁺ exchanger by activating guanylate cyclase in guinea pig cardiac myocytes.
Wei J, Watanabe Y, Takeuchi K, Yamashita K, Tashiro M, Kita S, Iwamoto T, Watanabe H, Kimura J. Wei J, et al. Pflugers Arch. 2016 Apr;468(4):693-703. doi: 10.1007/s00424-015-1763-8. Epub 2015 Dec 3. Pflugers Arch. 2016. PMID: 26631169 - Understanding the physiology of the asymptomatic diaphragm of the M1592V hyperkalemic periodic paralysis mouse.
Ammar T, Lin W, Higgins A, Hayward LJ, Renaud JM. Ammar T, et al. J Gen Physiol. 2015 Dec;146(6):509-25. doi: 10.1085/jgp.201511476. J Gen Physiol. 2015. PMID: 26621775 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials
Miscellaneous