A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma - PubMed (original) (raw)

Comparative Study

doi: 10.1007/BF02602776.

Affiliations

• PMID: 8781117
• DOI: 10.1007/BF02602776

Comparative Study

A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma

B Gaugler et al. Immunogenetics. 1996.

Abstract

Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.

PubMed Disclaimer

Similar articles

• A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.
  Van den Eynde B, Peeters O, De Backer O, Gaugler B, Lucas S, Boon T. Van den Eynde B, et al. J Exp Med. 1995 Sep 1;182(3):689-98. doi: 10.1084/jem.182.3.689. J Exp Med. 1995. PMID: 7544395 Free PMC article.
• A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription.
  Van Den Eynde BJ, Gaugler B, Probst-Kepper M, Michaux L, Devuyst O, Lorge F, Weynants P, Boon T. Van Den Eynde BJ, et al. J Exp Med. 1999 Dec 20;190(12):1793-800. doi: 10.1084/jem.190.12.1793. J Exp Med. 1999. PMID: 10601354 Free PMC article.
• Tumor associated antigens in human renal cell carcinoma: MHC restricted recognition by cytotoxic T lymphocytes.
  Bernhard H, Jäger E, Maeurer MJ, Meyer zum Büschenfelde KH, Knuth A. Bernhard H, et al. Tissue Antigens. 1996 Jul;48(1):22-31. doi: 10.1111/j.1399-0039.1996.tb02601.x. Tissue Antigens. 1996. PMID: 8864171
• Genes coding for tumor antigens recognized by human cytolytic T lymphocytes.
  Coulie PG, Weynants P, Lehmann F, Herman J, Brichard V, Wölfel T, Van Pel A, De Plaen E, Brasseur F, Boon T. Coulie PG, et al. J Immunother Emphasis Tumor Immunol. 1993 Aug;14(2):104-9. doi: 10.1097/00002371-199308000-00004. J Immunother Emphasis Tumor Immunol. 1993. PMID: 8280701 Review.
• Identification of genes coding for tumor antigens recognized by cytolytic T lymphocytes.
  De Plaen E, Lurquin C, Lethé B, van der Bruggen P, Brichard V, Renauld JC, Coulie P, Van Pel A, Boon T. De Plaen E, et al. Methods. 1997 Jun;12(2):125-42. doi: 10.1006/meth.1997.0462. Methods. 1997. PMID: 9184377 Review.

Cited by

• Antigenic targets in clear cell renal cell carcinoma.
  Schindler NR, Braun DA. Schindler NR, et al. Kidney Cancer. 2023 Aug 11;7(1):81-91. doi: 10.3233/KCA-230006. eCollection 2023. Kidney Cancer. 2023. PMID: 38014393 Free PMC article. Review.
• Current and future perspectives on CAR-T cell therapy for renal cell carcinoma: A comprehensive review.
  Kim TJ, Lee YH, Koo KC. Kim TJ, et al. Investig Clin Urol. 2022 Sep;63(5):486-498. doi: 10.4111/icu.20220103. Investig Clin Urol. 2022. PMID: 36067994 Free PMC article. Review.
• Downregulation of mapk/mak/mrk overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus.
  Sopić M, Ninić A, Ostanek B, Bojanin D, Milenković T, Munjas J, Mihajlović M, Vekić J, Marc J, Spasojević-Kalimanovska V. Sopić M, et al. J Med Biochem. 2022 Jul 29;41(3):282-289. doi: 10.5937/jomb0-33220. J Med Biochem. 2022. PMID: 36042901 Free PMC article.
• The A to I editing landscape in melanoma and its relation to clinical outcome.
  Amweg A, Tusup M, Cheng P, Picardi E, Dummer R, Levesque MP, French LE, Guenova E, Läuchli S, Kundig T, Mellett M, Pascolo S. Amweg A, et al. RNA Biol. 2022 Jan;19(1):996-1006. doi: 10.1080/15476286.2022.2110390. RNA Biol. 2022. PMID: 35993275 Free PMC article.
• Therapeutic Cancer Vaccines-Antigen Discovery and Adjuvant Delivery Platforms.
  Alarcon NO, Jaramillo M, Mansour HM, Sun B. Alarcon NO, et al. Pharmaceutics. 2022 Jul 11;14(7):1448. doi: 10.3390/pharmaceutics14071448. Pharmaceutics. 2022. PMID: 35890342 Free PMC article. Review.

References

1. 1. J Exp Med. 1994 Jul 1;180(1):35-42 - PubMed
2. 1. JAMA. 1994 Mar 23-30;271(12):907-13 - PubMed
3. 1. Annu Rev Immunol. 1994;12:337-65 - PubMed
4. 1. Arch Surg. 1990 Feb;125(2):200-5 - PubMed
5. 1. Science. 1995 Sep 1;269(5228):1281-4 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

• Research Materials

  • Cellosaurus - a cell line knowledge resource
  • NCI CPTC Antibody Characterization Program