Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts - PubMed (original) (raw)

Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts

S Tajima et al. J Dermatol Sci. 1996 Mar.

Abstract

Ascorbic acid is a potent stimulator for type I and III collagen expression in human skin fibroblasts; stimulation of type I and III collagen synthesis and their mRNA levels by ascorbic acid has been reported previously. Nuclear run-on experiments demonstrated that ascorbic acid enhanced the transcription of type I and III collagen genes 4- and 3.4-fold respectively, whereas transcription of type IV collagen was slightly stimulated (1.7-fold). The results suggest that ascorbic acid preferentially enhanced type I and III collagen transcription.

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