Cdk inhibitors in development and cancer - PubMed (original) (raw)
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Cdk inhibitors in development and cancer
J W Harper et al. Curr Opin Genet Dev. 1996 Feb.
Abstract
Activation of cyclin-dependent kinases is the primary control point of cell proliferation. Recent advances in the understanding of cell-cycle regulation have uncovered two families of proteins that bind and inhibit these kinases. These proteins are likely mediators of development and differentiation, and may provide molecular connections between the pathways of development and tumorigenesis.
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