Disease mechanism: unravelling Wiskott-Aldrich syndrome - PubMed (original) (raw)
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Disease mechanism: unravelling Wiskott-Aldrich syndrome
T Kirchhausen et al. Curr Biol. 1996.
Free article
Abstract
The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.
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