To kill or to cure: options in host defense against viral infection - PubMed (original) (raw)
Review
To kill or to cure: options in host defense against viral infection
L G Guidotti et al. Curr Opin Immunol. 1996 Aug.
Abstract
It is generally thought that viral clearance is mediated primarily by antigen-specific T cell responses that destroy infected cells. This assumption may not be true for all viruses. Recent studies using a transgenic mouse model of hepatitis B virus infection have shown that adoptively transferred, virus-specific cytotoxic T cells can abolish hepatitis B virus gene expression and replication in the liver without killing the hepatocytes. This effect is mediated by interferon-gamma and tumor necrosis factor-alpha, which are secreted by the cytotoxic T lymphocytes following antigen recognition. Similar noncytopathic cytokine-dependent 'curative' processes also occur in this model during an unrelated infection of the liver. Intracellular viral inactivation mechanisms such as these could greatly amplify the protective effects of the immune response. Research has also been carried out to clarify the relevance of curative versus destructive mechanisms of viral clearance in other models of viral infection.
Similar articles
- Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.
Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Schreiber R, Chisari FV. Guidotti LG, et al. Immunity. 1996 Jan;4(1):25-36. doi: 10.1016/s1074-7613(00)80295-2. Immunity. 1996. PMID: 8574849 - Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis.
Chisari FV. Chisari FV. Curr Top Microbiol Immunol. 1996;206:149-73. doi: 10.1007/978-3-642-85208-4_9. Curr Top Microbiol Immunol. 1996. PMID: 8608715 Review. - Cytokine-induced viral purging--role in viral pathogenesis.
Guidotti LG, Chisari FV. Guidotti LG, et al. Curr Opin Microbiol. 1999 Aug;2(4):388-91. doi: 10.1016/s1369-5274(99)80068-x. Curr Opin Microbiol. 1999. PMID: 10490351 Review. - Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses.
Kägi D, Hengartner H. Kägi D, et al. Curr Opin Immunol. 1996 Aug;8(4):472-7. doi: 10.1016/s0952-7915(96)80033-1. Curr Opin Immunol. 1996. PMID: 8794015 Review. - Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.
Guidotti LG, Borrow P, Hobbs MV, Matzke B, Gresser I, Oldstone MB, Chisari FV. Guidotti LG, et al. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4589-94. doi: 10.1073/pnas.93.10.4589. Proc Natl Acad Sci U S A. 1996. PMID: 8643448 Free PMC article.
Cited by
- Cyanobacteria and Algae-Derived Bioactive Metabolites as Antiviral Agents: Evidence, Mode of Action, and Scope for Further Expansion; A Comprehensive Review in Light of the SARS-CoV-2 Outbreak.
Pradhan B, Nayak R, Patra S, Bhuyan PP, Dash SR, Ki JS, Adhikary SP, Ragusa A, Jena M. Pradhan B, et al. Antioxidants (Basel). 2022 Feb 10;11(2):354. doi: 10.3390/antiox11020354. Antioxidants (Basel). 2022. PMID: 35204236 Free PMC article. Review. - Early events in hepatitis B infection: the role of inoculum dose.
Ciupe SM, Vaidya NK, Forde JE. Ciupe SM, et al. Proc Biol Sci. 2021 Feb 10;288(1944):20202715. doi: 10.1098/rspb.2020.2715. Epub 2021 Feb 10. Proc Biol Sci. 2021. PMID: 33563115 Free PMC article. - Role of alcohol in pathogenesis of hepatitis B virus infection.
Ganesan M, Eikenberry A, Poluektova LY, Kharbanda KK, Osna NA. Ganesan M, et al. World J Gastroenterol. 2020 Mar 7;26(9):883-903. doi: 10.3748/wjg.v26.i9.883. World J Gastroenterol. 2020. PMID: 32206001 Free PMC article. Review. - Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells.
Nguyen S, Deleage C, Darko S, Ransier A, Truong DP, Agarwal D, Japp AS, Wu VH, Kuri-Cervantes L, Abdel-Mohsen M, Del Rio Estrada PM, Ablanedo-Terrazas Y, Gostick E, Hoxie JA, Zhang NR, Naji A, Reyes-Terán G, Estes JD, Price DA, Douek DC, Deeks SG, Buggert M, Betts MR. Nguyen S, et al. Sci Transl Med. 2019 Dec 18;11(523):eaax4077. doi: 10.1126/scitranslmed.aax4077. Sci Transl Med. 2019. PMID: 31852798 Free PMC article. - Humanized Mouse Models for the Study of Hepatitis C and Host Interactions.
Yong KSM, Her Z, Chen Q. Yong KSM, et al. Cells. 2019 Jun 17;8(6):604. doi: 10.3390/cells8060604. Cells. 2019. PMID: 31213010 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical