Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant Sabra rat - PubMed (original) (raw)
Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant Sabra rat
D Rees et al. Hypertension. 1996 Sep.
Abstract
We examined the role of nitric oxide (NO) in the inherited resistance or susceptibility to hypertension in the Sabra hypertension-prone (SBH) and hypertension-resistant (SBN) rat. Basal mean arterial blood pressure was significantly greater in SBH than in SBN rats. Phenylephrine elevated blood pressure to a similar extent in both substrains, whereas the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA) had a greater pressor effect in SBN rats. The vasoconstrictor potency of phenylephrine was significantly higher in endothelium-intact aortic rings from the SBH rat, whereas the vasoconstrictor potency of L-NMMA was higher in those from the SBN substrain. Acetylcholine-induced endothelium-dependent relaxation was greater in aortic rings from SBN rats. The vasodilator potency of glyceryl trinitrate was significantly higher in aortic rings from SBH rats and was enhanced after endothelium removal. Both the activity of calcium-dependent NO synthase from aortic endothelial cells and the basal concentration of nitrite/nitrate in plasma were significantly greater in SBN than in SBH rats. In normotensive Wistar rats, basal mean arterial blood pressure, the pressor effect of L-NMMA, endothelial NO synthase activity, and plasma nitrite/ nitrate concentrations were all between the values in SBH and SBN rats. These results indicate that a decrease in NO generation plays a role in the susceptibility of SBH rats to hypertension. Furthermore, the resistance to hypertension in the SBN strain may be related to increased NO generation.
Similar articles
- Nitric oxide synthase and renin-angiotensin system gene expression in salt-sensitive and salt-resistant Sabra rats.
Lippoldt A, Gross V, Schneider K, Hansson A, Nadaud S, Schneider W, Bader M, Yagil C, Yagil Y, Luft FC. Lippoldt A, et al. Hypertension. 1997 Sep;30(3 Pt 1):409-15. doi: 10.1161/01.hyp.30.3.409. Hypertension. 1997. PMID: 9314425 - Disparate expression of the AVP gene in Sabra hypertension-prone and hypertension-resistant rats.
Yagil C, Ben-Ishay D, Yagil Y. Yagil C, et al. Am J Physiol. 1996 Oct;271(4 Pt 2):F806-13. doi: 10.1152/ajprenal.1996.271.4.F806. Am J Physiol. 1996. PMID: 8898010 - Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of slat sensitivity and resistance.
Yagil C, Katni G, Rubattu S, Stolpe C, Kreutz R, Lindpaintner K, Ganten D, Ben-Ishay D, Yagil Y. Yagil C, et al. J Hypertens. 1996 Oct;14(10):1175-82. doi: 10.1097/00004872-199610000-00004. J Hypertens. 1996. PMID: 8906515 - Genetic basis of salt-susceptibility in the Sabra rat model of hypertension.
Yagil Y, Yagil C. Yagil Y, et al. Kidney Int. 1998 Jun;53(6):1493-500. doi: 10.1046/j.1523-1755.1998.00932.x. Kidney Int. 1998. PMID: 9607181 Review. - Nitric oxide and hypertension in 1995.
Dominiczak AF, Bohr DF. Dominiczak AF, et al. Curr Opin Nephrol Hypertens. 1996 Mar;5(2):174-80. doi: 10.1097/00041552-199603000-00014. Curr Opin Nephrol Hypertens. 1996. PMID: 8744542 Review.
Cited by
- Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.
Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y. Tian XY, et al. Antioxid Redox Signal. 2012 Feb 15;16(4):363-73. doi: 10.1089/ars.2010.3874. Epub 2011 Dec 2. Antioxid Redox Signal. 2012. PMID: 21951274 Free PMC article. - Dynamics of NO motion in solid-state [Co(tetraphenylporphinato)(NO)].
Grande LM, Noll BC, Oliver AG, Scheidt WR. Grande LM, et al. Inorg Chem. 2010 Jul 19;49(14):6552-7. doi: 10.1021/ic1003462. Inorg Chem. 2010. PMID: 20545325 Free PMC article. - Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.
List EO, Sackmann-Sala L, Berryman DE, Funk K, Kelder B, Gosney ES, Okada S, Ding J, Cruz-Topete D, Kopchick JJ. List EO, et al. Endocr Rev. 2011 Jun;32(3):356-86. doi: 10.1210/er.2010-0009. Epub 2010 Dec 1. Endocr Rev. 2011. PMID: 21123740 Free PMC article. Review. - Nitric oxide: discovery and impact on clinical medicine.
Moncada S. Moncada S. J R Soc Med. 1999 Apr;92(4):164-9. doi: 10.1177/014107689909200402. J R Soc Med. 1999. PMID: 10450191 Free PMC article. Review. No abstract available. - Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.
Franco Mdo C, Fortes ZB, Akamine EH, Kawamoto EM, Scavone C, de Britto LR, Muscara MN, Teixeira SA, Tostes RC, Carvalho MH, Nigro D. Franco Mdo C, et al. J Physiol. 2004 Jul 1;558(Pt 1):239-48. doi: 10.1113/jphysiol.2004.064055. Epub 2004 May 7. J Physiol. 2004. PMID: 15133063 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical