Multiple genes coding for the androgen-regulated major urinary proteins of the mouse - PubMed (original) (raw)

Multiple genes coding for the androgen-regulated major urinary proteins of the mouse

N D Hastie et al. Cell. 1979 Jun.

Abstract

We have purified a cDNA fragment complementary to the mRNA coding for one of the major urinary proteins (MUPs) synthesized in the mouse liver. Using this cDNA as a hybridization probe, we have shown that the level of MUP mRNA is lower in the livers of females and castrated males than in those of males. The addition of testosterone to females and castrated males results in an increase in the concentration of the mRNA to levels found in males. There are approximately 15 gene per haploid genome coding for the MUPs; this allows a possible new interpretation of some of the genetic data concerning the regulation of levels of the different MUPs in the urine (Szoka and Paigen, 1978). Finally, we have shown that mouse MUP and rat alpha 2u-globulin mRNA share common sequences, but that there are surprising differences in gene number and regulation of the genes in these two closely related animals.

PubMed Disclaimer

Cited by

Differential expression in male and female mouse liver of very similar mRNAs specified by two group 1 major urinary protein genes.
McIntosh I, Bishop JO. McIntosh I, et al. Mol Cell Biol. 1989 May;9(5):2202-7. doi: 10.1128/mcb.9.5.2202-2207.1989. Mol Cell Biol. 1989. PMID: 2747646 Free PMC article.
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice.
Al-Shawi R, Burke J, Jones CT, Simons JP, Bishop JO. Al-Shawi R, et al. Mol Cell Biol. 1988 Nov;8(11):4821-8. doi: 10.1128/mcb.8.11.4821-4828.1988. Mol Cell Biol. 1988. PMID: 2850469 Free PMC article.
Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver.
Shahan K, Denaro M, Gilmartin M, Shi Y, Derman E. Shahan K, et al. Mol Cell Biol. 1987 May;7(5):1947-54. doi: 10.1128/mcb.7.5.1947-1954.1987. Mol Cell Biol. 1987. PMID: 3600653 Free PMC article.
Genome-wide estimation of transcript concentrations from spotted cDNA microarray data.
Frigessi A, van de Wiel MA, Holden M, Svendsrud DH, Glad IK, Lyng H. Frigessi A, et al. Nucleic Acids Res. 2005 Oct 4;33(17):e143. doi: 10.1093/nar/gni141. Nucleic Acids Res. 2005. PMID: 16204447 Free PMC article.
Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice.
Soares Vda C, Gubits RM, Feigelson P, Costantini F. Soares Vda C, et al. Mol Cell Biol. 1987 Oct;7(10):3749-58. doi: 10.1128/mcb.7.10.3749-3758.1987. Mol Cell Biol. 1987. PMID: 2446121 Free PMC article.

Multiple genes coding for the androgen-regulated major urinary proteins of the mouse - PubMed (original) (raw)