Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors - PubMed (original) (raw)

Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors

H Li et al. Genomics. 1996.

Abstract

The human Gi-phase cyclins are important regulators of cell cycle progression that interact with various cyclin-dependent kinases and facilitate entry into S-phase. We have confirmed the localization of the human cyclin C (CCNC) gene to chromosome 6q21 and of human cyclin E (CCNE) to 19q12. The CCNC gene structure was also determined, and we have shown that it is deleted in a subset of acute lymphoblastic leukemias, including a patient sample containing a t(2;6)(p21;q15), with no apparent cytogenetic deletion. Single-strand conformational polymorphism analysis of the remaining CCNC allele from patients with a deletion of one allele established that there were no further mutations within the exons or the flanking intronic sequences. These results suggest either that haploinsufficiency of the cyclin C protein is sufficient to promote tumorigenesis or that the important tumor suppressor gene is linked to the CCNC locus.

PubMed Disclaimer

Cited by

Androgen receptor gene and hormonal therapy failure of prostate cancer.
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP. Koivisto P, et al. Am J Pathol. 1998 Jan;152(1):1-9. Am J Pathol. 1998. PMID: 9422516 Free PMC article. Review.
Autism and intellectual disability in a patient with two microdeletions in 6q16: a contiguous gene deletion syndrome?
Strunk D, Weber P, Röthlisberger B, Filges I. Strunk D, et al. Mol Cytogenet. 2016 Dec 3;9:88. doi: 10.1186/s13039-016-0299-8. eCollection 2016. Mol Cytogenet. 2016. PMID: 27980676 Free PMC article.
Motor Neuron and Pancreas Homeobox 1 (MNX1) Is Involved in Promoting Squamous Cervical Cancer Proliferation via Regulating Cyclin E.
Xiao L, Hong L, Zheng W. Xiao L, et al. Med Sci Monit. 2019 Aug 22;25:6304-6312. doi: 10.12659/MSM.914233. Med Sci Monit. 2019. PMID: 31436258 Free PMC article.
TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-κB Signaling.
Kawabata H, Azuma K, Ikeda K, Sugitani I, Kinowaki K, Fujii T, Osaki A, Saeki T, Horie-Inoue K, Inoue S. Kawabata H, et al. Int J Mol Sci. 2017 Sep 8;18(9):1931. doi: 10.3390/ijms18091931. Int J Mol Sci. 2017. PMID: 28885545 Free PMC article.
Cyclin C: The Story of a Non-Cycling Cyclin.
Ježek J, Smethurst DGJ, Stieg DC, Kiss ZAC, Hanley SE, Ganesan V, Chang KT, Cooper KF, Strich R. Ježek J, et al. Biology (Basel). 2019 Jan 4;8(1):3. doi: 10.3390/biology8010003. Biology (Basel). 2019. PMID: 30621145 Free PMC article. Review.

Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors - PubMed (original) (raw)