Mechanisms and molecules that control growth cone guidance - PubMed (original) (raw)
Review
Mechanisms and molecules that control growth cone guidance
C S Goodman. Annu Rev Neurosci. 1996.
Abstract
Neuronal growth cones traverse long distances along appropriate pathways to find their correct targets. This review presents an overview of the mechanisms and molecules that control these events. Secreted and cell surface ligands in the growth cone's environment bind to receptors on the growth cone's surface, trigger second-messenger signals, and lead to appropriate steering decisions. Growth cones appear to be guided by at least four different mechanisms: contact-mediated attraction, chemoattraction, contact-mediated repulsion, and chemorepulsion. These mechanisms are mediated by many different families of guidance molecules, including neural cell adhesion molecules of the immunoglobulin superfamily, netrins, and semaphorins, all of which appear to be highly conserved from worms and fruitflies to mice and humans. We are just beginning to gain insights into the functions of these and other molecules in the developing organism by the use of genetic analysis.
Similar articles
- The molecular biology of axon guidance.
Tessier-Lavigne M, Goodman CS. Tessier-Lavigne M, et al. Science. 1996 Nov 15;274(5290):1123-33. doi: 10.1126/science.274.5290.1123. Science. 1996. PMID: 8895455 Review. - [Guidance mechanisms in neuronal and axonal migration].
Tanaka DH, Yamauchi K, Murakami F. Tanaka DH, et al. Brain Nerve. 2008 Apr;60(4):405-13. Brain Nerve. 2008. PMID: 18421982 Review. Japanese. - Molecular mechanisms of axon guidance.
Dickson BJ. Dickson BJ. Science. 2002 Dec 6;298(5600):1959-64. doi: 10.1126/science.1072165. Science. 2002. PMID: 12471249 Review. - Semaphorins and their receptors in olfactory axon guidance.
Pasterkamp RJ, Ruitenberg MJ, Verhaagen J. Pasterkamp RJ, et al. Cell Mol Biol (Noisy-le-grand). 1999 Sep;45(6):763-79. Cell Mol Biol (Noisy-le-grand). 1999. PMID: 10541474 Review. - Semaphorins: repulsive guidance molecules show their attractive side.
Püschel AW. Püschel AW. Nat Neurosci. 1999 Sep;2(9):777-8. doi: 10.1038/12140. Nat Neurosci. 1999. PMID: 10461211
Cited by
- Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods.
Igarashi M. Igarashi M. Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(7):358-377. doi: 10.2183/pjab.95.026. Proc Jpn Acad Ser B Phys Biol Sci. 2019. PMID: 31406059 Free PMC article. Review. - Silicon Carbide Technology for Advanced Human Healthcare Applications.
Saddow SE. Saddow SE. Micromachines (Basel). 2022 Feb 22;13(3):346. doi: 10.3390/mi13030346. Micromachines (Basel). 2022. PMID: 35334637 Free PMC article. Review. - How to innervate a simple gut: familiar themes and unique aspects in the formation of the insect enteric nervous system.
Copenhaver PF. Copenhaver PF. Dev Dyn. 2007 Jul;236(7):1841-64. doi: 10.1002/dvdy.21138. Dev Dyn. 2007. PMID: 17420985 Free PMC article. Review. - Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment.
Klebanov O, Nitzan A, Raz D, Barzilai A, Solomon AS. Klebanov O, et al. Graefes Arch Clin Exp Ophthalmol. 2009 Jan;247(1):73-86. doi: 10.1007/s00417-008-0945-x. Epub 2008 Sep 25. Graefes Arch Clin Exp Ophthalmol. 2009. PMID: 18815803 - Neuropilar projections of the anterior gastric receptor neuron in the stomatogastric ganglion of the Jonah crab, Cancer borealis.
Goeritz ML, Bowers MR, Slepian B, Marder E. Goeritz ML, et al. PLoS One. 2013 Dec 3;8(12):e79306. doi: 10.1371/journal.pone.0079306. eCollection 2013. PLoS One. 2013. PMID: 24312448 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources