Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage - PubMed (original) (raw)
Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage
S E Akopov et al. Stroke. 1996 Oct.
Abstract
Background and purpose: This study was performed to study the dynamics of polymorphonuclear leukocyte (PMNL) accumulation in human cerebral infarction and its association with neurological outcome and brain lesion.
Methods: A total of 88 patients diagnosed as having hemispheric ischemic stroke were examined. PMNL accumulation was studied using technetium-99m hexamethylpropyleneamine oxime (99mTc HMPAO)-labeled leukocyte brain single-photon emission computed tomography (SPECT). Volume of brain infarction was evaluated by CT scan. The Mathew Scale was used for neurological assessment. Dynamics of PMNL accumulation was studied at 3 to 6, 6 to 12, and 12 to 24 hours and 6 to 9, 28 to 30, and 90 days after stroke onset. In parallel, at admission, at 6 to 9 days, and at 28 to 30 days neurological outcome and infarction volume were evaluated.
Results: Generally, PMNL accumulation progressively increased during 6 to 24 hours after stroke, remained at a high level up to 6 to 9 days and then declined. With the use of cluster analysis, all patients were subdivided into three groups: patients with severe PMNL accumulation that dramatically increased within 12 hours after stroke onset and persisted even at 28 to 30 days (group A); those with moderate PMNL accumulation that significantly decreased at 30 days (group B); and those with mild PMNL accumulation that decreased at 6 to 9 days (group C). Baseline neurological deficit and brain tissue damage at admission appear to be at a similar level for all groups of patients. In dynamics, however, in patients with severe PMNL accumulation, neurological outcome was worse and infarction volume larger than in patients with less marked PMNL accumulation.
Conclusions: The present clinical study confirms that PMNLs intensively accumulate in the regions of cerebral infarction. The present study revealed that this accumulation correlated with the severity of the brain tissue damage and poor neurological outcome.
Similar articles
- Single-photon emission computed tomography using hexamethylpropyleneamine oxime in the prognosis of acute cerebral infarction.
Bowler JV, Wade JP, Jones BE, Nijran K, Steiner TJ. Bowler JV, et al. Stroke. 1996 Jan;27(1):82-6. doi: 10.1161/01.str.27.1.82. Stroke. 1996. PMID: 8553409 - [In-111-labeled leukocyte brain SPECT imaging in acute ischemic stroke in man].
Fujinuma K, Sakai F, Iizuka T, Kitai N. Fujinuma K, et al. Rinsho Shinkeigaku. 1997 Jan;37(1):13-20. Rinsho Shinkeigaku. 1997. PMID: 9146067 Japanese. - Sensitivity and specificity of 99mTc-HMPAO SPECT cerebral perfusion measurements during the first 48 hours for the localization of cerebral infarction.
Baird AE, Austin MC, McKay WJ, Donnan GA. Baird AE, et al. Stroke. 1997 May;28(5):976-80. doi: 10.1161/01.str.28.5.976. Stroke. 1997. PMID: 9158636 Clinical Trial. - [99mTc-hexamethylpropyleneamine oxime (HMPAO)--its diagnostic potentials for assessing the cerebral blood supply (a review)].
Krotkov FF, Petunina IV. Krotkov FF, et al. Med Radiol (Mosk). 1989 Nov;34(11):29-35. Med Radiol (Mosk). 1989. PMID: 2685504 Review. Russian. No abstract available.
Cited by
- Predictive value of neutrophil to apolipoprotein A1 ratio in patients with acute ischaemic stroke.
Chen C, Li S, Sun F, Chen Y, Qiu H, Huang J, Jin Y, Huang J, Xu J, Jiang Z, Li K, Wang Y, Lin H. Chen C, et al. Brain Commun. 2024 Mar 21;6(2):fcae091. doi: 10.1093/braincomms/fcae091. eCollection 2024. Brain Commun. 2024. PMID: 38550307 Free PMC article. - Immunothrombosis in neurovascular disease.
Denorme F, Ajanel A, Campbell RA. Denorme F, et al. Res Pract Thromb Haemost. 2023 Dec 20;8(1):102298. doi: 10.1016/j.rpth.2023.102298. eCollection 2024 Jan. Res Pract Thromb Haemost. 2023. PMID: 38292352 Free PMC article. - Association between Systemic Immune-Inflammation Index and Systemic Inflammation Response Index and Outcomes of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
Han J, Yang L, Lou Z, Zhu Y. Han J, et al. Ann Indian Acad Neurol. 2023 Sep-Oct;26(5):655-662. doi: 10.4103/aian.aian_85_23. Epub 2023 Jul 20. Ann Indian Acad Neurol. 2023. PMID: 38022472 Free PMC article. Review. - Targeting Neutrophil α9 Improves Functional Outcomes After Stroke in Mice With Obesity-Induced Hyperglycemia.
Patel RB, Dhanesha N, Sutariya B, Ghatge M, Doddapattar P, Barbhuyan T, Kumskova M, Leira EC, Chauhan AK. Patel RB, et al. Stroke. 2023 Sep;54(9):2409-2419. doi: 10.1161/STROKEAHA.123.042714. Epub 2023 Jul 14. Stroke. 2023. PMID: 37449422 Free PMC article. - Effects of remote ischemic postconditioning on the pro-inflammatory neutrophils of peripheral blood in acute cerebral infarction.
Liang Z, Qiu L, Wang X, Feng L, Hao Y, Yang F, Ma D, Feng J. Liang Z, et al. Aging (Albany NY). 2023 May 30;15(10):4481-4497. doi: 10.18632/aging.204751. Epub 2023 May 30. Aging (Albany NY). 2023. PMID: 37253636 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources