Complement factor D, a novel serine protease - PubMed (original) (raw)

Review

Complement factor D, a novel serine protease

J E Volanakis et al. Protein Sci. 1996 Apr.

Abstract

Factor D is unique among serine proteases in that it requires neither enzymatic cleavage for expression of proteolytic activity nor inactivation by a serpin for its control. Regulation of factor D activity is instead attained by a novel mechanism that depends on reversible conformational changes for expression and control of catalytic activity. These conformational changes are believed to be induced by the single natural substrate, C3bB, and to result in realignment of the catalytic triad, the specificity pocket, and the nonspecific substrate binding site, all of which have atypical conformations. Mutational studies have defined structural determinants responsible for these unique structural features of factor D and for the resultant low reactivity with synthetic esters.

PubMed Disclaimer

Similar articles

• Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
  Jing H, Babu YS, Moore D, Kilpatrick JM, Liu XY, Volanakis JE, Narayana SV. Jing H, et al. J Mol Biol. 1998 Oct 9;282(5):1061-81. doi: 10.1006/jmbi.1998.2089. J Mol Biol. 1998. PMID: 9753554
• Crystal structure of a complement factor D mutant expressing enhanced catalytic activity.
  Kim S, Narayana SV, Volanakis JE. Kim S, et al. J Biol Chem. 1995 Oct 13;270(41):24399-405. doi: 10.1074/jbc.270.41.24399. J Biol Chem. 1995. PMID: 7592653
• Mutational analysis of the substrate binding site of human complement factor D.
  Kim S, Narayana SV, Volanakis JE. Kim S, et al. Biochemistry. 1994 Dec 6;33(48):14393-9. doi: 10.1021/bi00252a004. Biochemistry. 1994. PMID: 7981199
• Structural biology of the alternative pathway convertase.
  Xu Y, Narayana SV, Volanakis JE. Xu Y, et al. Immunol Rev. 2001 Apr;180:123-35. doi: 10.1034/j.1600-065x.2001.1800111.x. Immunol Rev. 2001. PMID: 11414354 Review.
• The atypical serine proteases of the complement system.
  Arlaud GJ, Volanakis JE, Thielens NM, Narayana SV, Rossi V, Xu Y. Arlaud GJ, et al. Adv Immunol. 1998;69:249-307. Adv Immunol. 1998. PMID: 9646846 Review. No abstract available.

Cited by

• Secreted proteases control autolysin-mediated biofilm growth of Staphylococcus aureus.
  Chen C, Krishnan V, Macon K, Manne K, Narayana SV, Schneewind O. Chen C, et al. J Biol Chem. 2013 Oct 11;288(41):29440-52. doi: 10.1074/jbc.M113.502039. Epub 2013 Aug 22. J Biol Chem. 2013. PMID: 23970550 Free PMC article.
• Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer-Simons syndrome).
  Corvillo F, González-Sánchez L, López-Lera A, Arjona E, Ceccarini G, Santini F, Araújo-Vilar D, Brown RJ, Villarroya J, Villarroya F, Rodríguez de Córdoba S, Caballero T, Nozal P, López-Trascasa M. Corvillo F, et al. Int J Mol Sci. 2021 Jun 21;22(12):6608. doi: 10.3390/ijms22126608. Int J Mol Sci. 2021. PMID: 34205507 Free PMC article.
• Molecular cloning and characterization of glucanase inhibitor proteins: coevolution of a counterdefense mechanism by plant pathogens.
  Rose JK, Ham KS, Darvill AG, Albersheim P. Rose JK, et al. Plant Cell. 2002 Jun;14(6):1329-45. doi: 10.1105/tpc.002253. Plant Cell. 2002. PMID: 12084830 Free PMC article.
• Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D.
  Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, Homma Y, Fujita T. Takahashi M, et al. J Exp Med. 2010 Jan 18;207(1):29-37. doi: 10.1084/jem.20090633. Epub 2009 Dec 28. J Exp Med. 2010. PMID: 20038603 Free PMC article.
• Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D.
  Murakami Y, Nishigori M, Yagi H, Osaki T, Wakabayashi M, Shirai M, Son C, Iba Y, Minatoya K, Kusano K, Tomita T, Ishibashi-Ueda H, Matsuda H, Minamino N. Murakami Y, et al. Proteome Sci. 2023 Aug 5;21(1):11. doi: 10.1186/s12953-023-00212-x. Proteome Sci. 2023. PMID: 37543598 Free PMC article.

References

1. 1. J Exp Med. 1980 Mar 1;151(3):501-16 - PubMed
2. 1. J Mol Biol. 1972 Jun 14;67(1):151-63 - PubMed
3. 1. Nature. 1969 Jan 18;221(5177):235-42 - PubMed
4. 1. Biochemistry. 1989 May 2;28(9):3629-37 - PubMed
5. 1. J Immunol. 1994 Apr 1;152(7):3645-53 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal