YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels - PubMed (original) (raw)
YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels
A Shrivastava et al. Proc Natl Acad Sci U S A. 1996.
Abstract
The c-Myc oncoprotein has previously been shown to associate with transcription regulator YY1 and to inhibit its activity. We show herein that endogenous c-Myc and YY1 associate in vivo and that changes in c-Myc levels, which accompany mitogenic stimulation or differentiation of cultured cells, affect the ratio of free to c-Myc-associated YY1. We have also investigated the mechanism by which association with c-Myc inhibits YY1's ability to regulate transcription. c-Myc does not block binding of YY1 to DNA. However, protein association studies suggest that c-Myc interferes with the ability of YY1 to contact basal transcription proteins TATA-binding protein and TFIIB.
Similar articles
- Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K. Shrivastava A, et al. Science. 1993 Dec 17;262(5141):1889-92. doi: 10.1126/science.8266081. Science. 1993. PMID: 8266081 - YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc.
Austen M, Cerni C, Lüscher-Firzlaff JM, Lüscher B. Austen M, et al. Oncogene. 1998 Jul 30;17(4):511-20. doi: 10.1038/sj.onc.1201968. Oncogene. 1998. PMID: 9696045 - Physical Interaction of Human Yin Yang 1 Protein with DNA.
Figiel M, Górecki A. Figiel M, et al. Crit Rev Oncog. 2017;22(1-2):75-97. doi: 10.1615/CritRevOncog.2017020976. Crit Rev Oncog. 2017. PMID: 29604938 Review. - Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?
Thomas MJ, Seto E. Thomas MJ, et al. Gene. 1999 Aug 20;236(2):197-208. doi: 10.1016/s0378-1119(99)00261-9. Gene. 1999. PMID: 10452940 Review.
Cited by
- A Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells.
Gupta S, Silveira DA, Hashimoto RF, Mombach JCM. Gupta S, et al. Biology (Basel). 2022 Mar 22;11(4):480. doi: 10.3390/biology11040480. Biology (Basel). 2022. PMID: 35453680 Free PMC article. - Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4+ T-Cell Compartments.
Merino-Wong M, Niemeyer BA, Alansary D. Merino-Wong M, et al. Front Immunol. 2021 May 21;12:687242. doi: 10.3389/fimmu.2021.687242. eCollection 2021. Front Immunol. 2021. PMID: 34093590 Free PMC article. - YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates.
Bhaskar Rao D, Panneerpandian P, Balakrishnan K, Ganesan K. Bhaskar Rao D, et al. J Cell Commun Signal. 2021 Jun;15(2):251-267. doi: 10.1007/s12079-021-00608-4. Epub 2021 Feb 23. J Cell Commun Signal. 2021. PMID: 33620645 Free PMC article. - The Two Sides of YY1 in Cancer: A Friend and a Foe.
Sarvagalla S, Kolapalli SP, Vallabhapurapu S. Sarvagalla S, et al. Front Oncol. 2019 Nov 20;9:1230. doi: 10.3389/fonc.2019.01230. eCollection 2019. Front Oncol. 2019. PMID: 31824839 Free PMC article. Review. - Zinc-finger protein YY1 suppresses tumor growth of human nasopharyngeal carcinoma by inactivating c-Myc-mediated microRNA-141 transcription.
Li M, Liu Y, Wei Y, Wu C, Meng H, Niu W, Zhou Y, Wang H, Wen Q, Fan S, Li Z, Li X, Zhou J, Cao K, Xiong W, Zeng Z, Li X, Qiu Y, Li G, Zhou M. Li M, et al. J Biol Chem. 2019 Apr 12;294(15):6172-6187. doi: 10.1074/jbc.RA118.006281. Epub 2019 Feb 4. J Biol Chem. 2019. PMID: 30718276 Free PMC article.
References
- Nature. 1984 Aug 16-22;310(5978):592-4 - PubMed
- Science. 1994 Apr 8;264(5156):251-4 - PubMed
- J Immunol. 1985 Apr;134(4):2727-33 - PubMed
- Annu Rev Immunol. 1986;4:317-38 - PubMed
- Adv Cancer Res. 1986;47:189-234 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources