Wnt-mediated relocalization of dishevelled proteins - PubMed (original) (raw)

. 1996 Jul-Aug;32(7):441-5.

doi: 10.1007/BF02723007.

Affiliations

• PMID: 8856345
• DOI: 10.1007/BF02723007

Wnt-mediated relocalization of dishevelled proteins

S A Steitz et al. In Vitro Cell Dev Biol Anim. 1996 Jul-Aug.

Abstract

The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution. One such element, the dishevelled gene product, becomes hyperphosphorylated and translocates to the plasma membrane in response to Wg (Yanagawa et al., 1995). We report here that the mouse Dishevelled-1 (Dvl-1) and Dishevelled-2 genes encode proteins that are differentially localized in Wnt-overexpressing PC12 cell lines (PC12/Wnt). Whereas Dvl-1 and Dvl-2 proteins are limited to the soluble fraction of parental PC12 cells, PC12/Wnt cells display a subset of Dvl-1 protein associated with the membrane and Dvl-2 protein with the cytoskeletal fraction. These results suggest a conserved role for Dvl in Wnt/wg signal transduction.

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