TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB - PubMed (original) (raw)

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

C Y Wang et al. Science. 1996.

Abstract

Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-kappaB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-kappaB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappaB, and have potential for improvement of the efficacy of cancer therapies.

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Comment in

• Life-death balance within the cell.
  Barinaga M. Barinaga M. Science. 1996 Nov 1;274(5288):724. doi: 10.1126/science.274.5288.724. Science. 1996. PMID: 8966553 No abstract available.
• Transcription factors, oncogenes, and apoptosis.
  White DW, Gilmore TD. White DW, et al. Science. 1997 Apr 11;276(5310):185. doi: 10.1126/science.276.5310.181f. Science. 1997. PMID: 9132938 No abstract available.

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