Elevated levels of anticardiolipin antibodies and epilepsy in lupus patients - PubMed (original) (raw)
Elevated levels of anticardiolipin antibodies and epilepsy in lupus patients
H H Liou et al. Lupus. 1996 Aug.
Abstract
To examine the association between anticardiolipin (aCL) antibodies and epilepsy, we investigated the serum titers of aCL antibodies in a total 252 systemic lupus erythematosus (SLE) patients recruited in a prospective study. Twenty-one cases with epilepsy which were not attributable to any causes other than SLE were identified after being followed-up for five years. The clinical manifestations were recorded and blood samples were tested for the presence of aCL antibodies (IgG, IgM and IgA isotypes). Among 21 patients with epilepsy, 12 (57.1%), 2 (9.5%) and 2 (9.5%), respectively, had elevated baseline serum levels of IgG, IgM and IgA aCL antibodies. There was a dose-response relationship between risk of seizure and the baseline serum level of aCL antibodies (P < 0.01). The odds ratio of developing seizure were 3.7 for those who had a high level of aCL antibodies compared with those without a detectable level of aCL antibodies as the referent. Our results indicate that epilepsy as a primary neuropsychiatric event among lupus patients is associated with a high titer of aCL antibodies.
Comment in
- Epilepsy and antiphospholipid antibodies in systemic lupus erythematosus patients.
Formiga F, Mitjavila F, Pac M, Moga I. Formiga F, et al. Lupus. 1997;6(5):486. doi: 10.1177/096120339700600515. Lupus. 1997. PMID: 9229372 No abstract available.
Similar articles
- Epilepsy and antiphospholipid antibodies in systemic lupus erythematosus patients.
Formiga F, Mitjavila F, Pac M, Moga I. Formiga F, et al. Lupus. 1997;6(5):486. doi: 10.1177/096120339700600515. Lupus. 1997. PMID: 9229372 No abstract available. - The value of IgA antiphospholipid testing for diagnosis of antiphospholipid (Hughes) syndrome in systemic lupus erythematosus.
Bertolaccini ML, Atsumi T, Escudero Contreras A, Khamashta MA, Hughes GR. Bertolaccini ML, et al. J Rheumatol. 2001 Dec;28(12):2637-43. J Rheumatol. 2001. PMID: 11764209 - Association between IgM anticardiolipin antibodies and deep venous thrombosis in patients without systemic lupus erythematosus.
Oger E, Lernyer C, Dueymes M, Le Moigne E, Bressolette L, Escoffre M, Youinou P, Mottier D. Oger E, et al. Lupus. 1997;6(5):455-61. doi: 10.1177/096120339700600508. Lupus. 1997. PMID: 9229365 - Significance of IgA antiphospholipid antibodies.
Wilson WA, Faghiri Z, Taheri F, Gharavi AE. Wilson WA, et al. Lupus. 1998;7 Suppl 2:S110-3. doi: 10.1177/096120339800700225. Lupus. 1998. PMID: 9814686 Review. - Anticardiolipin antibodies and cardiovascular disease.
Muir KW. Muir KW. J R Soc Med. 1995 Aug;88(8):433-6. J R Soc Med. 1995. PMID: 7562824 Free PMC article. Review. No abstract available.
Cited by
- Neuropsychiatric lupus.
Alkhotani A. Alkhotani A. Sultan Qaboos Univ Med J. 2013 Feb;13(1):19-25. Epub 2013 Feb 27. Sultan Qaboos Univ Med J. 2013. PMID: 23573378 Free PMC article. - The JAK-STAT Signaling Pathway in Epilepsy.
Sun H, Ma D, Cheng Y, Li J, Zhang W, Jiang T, Li Z, Li X, Meng H. Sun H, et al. Curr Neuropharmacol. 2023;21(10):2049-2069. doi: 10.2174/1570159X21666221214170234. Curr Neuropharmacol. 2023. PMID: 36518035 Free PMC article. Review. - Role of brain inflammation in epileptogenesis.
Choi J, Koh S. Choi J, et al. Yonsei Med J. 2008 Feb 29;49(1):1-18. doi: 10.3349/ymj.2008.49.1.1. Yonsei Med J. 2008. PMID: 18306464 Free PMC article. Review. - Pattern of MRI brain in neuro-psychiatric SLE. Effect of anti-phospholipid antibodies: A study at a tertiary care teaching hospital.
Parvez K, Al-Arfaj AR, Hamdani MA, Naseeb F, Daif A, Hussain S. Parvez K, et al. Pak J Med Sci. 2015 Sep-Oct;31(5):1182-7. doi: 10.12669/pjms.315.7975. Pak J Med Sci. 2015. PMID: 26649010 Free PMC article. - Antiphospholipid syndrome and vascular ischemic (occlusive) diseases: an overview.
Atanassova PA. Atanassova PA. Yonsei Med J. 2007 Dec 31;48(6):901-26. doi: 10.3349/ymj.2007.48.6.901. Yonsei Med J. 2007. PMID: 18159581 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous