Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen - PubMed (original) (raw)

Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen

E Takimoto et al. Science. 1996.

Abstract

Maternal hypertension is a common complication of pregnancy and its pathophysiology is poorly understood. This phenomenon was studied in an animal model by mating transgenic mice expressing components of the human renin-angiotensin system. When transgenic females expressing angiotensinogen were mated with transgenic males expressing renin, the pregnant females displayed a transient elevation of blood pressure in late pregnancy, due to secretion of placental human renin into the maternal circulation. Blood pressure returned to normal levels after delivery of the pups. Histopathologic examination revealed uniform enlargement of glomeruli associated with an increase in urinary protein excretion, myocardial hypertrophy, and necrosis and edema in the placenta. These mice may provide molecular insights into pregnancy-associated hypertension in humans.

PubMed Disclaimer

Comment in

• Mouse model for pregnancy problem?
  Gura T. Gura T. Science. 1996 Nov 8;274(5289):922. doi: 10.1126/science.274.5289.922. Science. 1996. PMID: 8966572 No abstract available.

Similar articles

• Mouse model for pregnancy problem?
  Gura T. Gura T. Science. 1996 Nov 8;274(5289):922. doi: 10.1126/science.274.5289.922. Science. 1996. PMID: 8966572 No abstract available.
• An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation.
  Saito T, Ishida J, Takimoto-Ohnishi E, Takamine S, Shimizu T, Sugaya T, Kato H, Matsuoka T, Nangaku M, Kon Y, Sugiyama F, Yagami K, Fukamizu A. Saito T, et al. FASEB J. 2004 Feb;18(2):388-90. doi: 10.1096/fj.03-0321fje. Epub 2003 Dec 19. FASEB J. 2004. PMID: 14688210
• Mice overexpressing both human angiotensinogen and human renin as a model of superimposed preeclampsia on chronic hypertension.
  Falcao S, Stoyanova E, Cloutier G, Maurice RL, Gutkowska J, Lavoie JL. Falcao S, et al. Hypertension. 2009 Dec;54(6):1401-7. doi: 10.1161/HYPERTENSIONAHA.109.137356. Epub 2009 Oct 12. Hypertension. 2009. PMID: 19822800
• Role of the renin-angiotensin system in blood pressure regulation and in human hypertension: new insights from molecular genetics.
  Corvol P, Jeunemaitre X, Charru A, Kotelevtsev Y, Soubrier F. Corvol P, et al. Recent Prog Horm Res. 1995;50:287-308. doi: 10.1016/b978-0-12-571150-0.50017-2. Recent Prog Horm Res. 1995. PMID: 7740162 Review. No abstract available.
• Recent advances in the study of renin and angiotensinogen genes: from molecules to the whole body.
  Tamura K, Umemura S, Fukamizu A, Ishii M, Murakami K. Tamura K, et al. Hypertens Res. 1995 Mar;18(1):7-18. doi: 10.1291/hypres.18.7. Hypertens Res. 1995. PMID: 7584914 Review.

Cited by

• Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsia.
  Xia Y, Ramin SM, Kellems RE. Xia Y, et al. Hypertension. 2007 Aug;50(2):269-75. doi: 10.1161/HYPERTENSIONAHA.107.091322. Epub 2007 Jun 18. Hypertension. 2007. PMID: 17576854 Free PMC article. Review. No abstract available.
• Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy-associated cardiomyopathy.
  Wang Y, Guo Z, Gao Y, Liang P, Shan Y, He J. Wang Y, et al. Cell Biosci. 2019 Oct 21;9:86. doi: 10.1186/s13578-019-0348-1. eCollection 2019. Cell Biosci. 2019. PMID: 31649814 Free PMC article.
• Animal models of preeclampsia.
  Podjarny E, Losonczy G, Baylis C. Podjarny E, et al. Semin Nephrol. 2004 Nov;24(6):596-606. doi: 10.1016/s0270-9295(04)00131-7. Semin Nephrol. 2004. PMID: 15529295 Free PMC article. Review.
• Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data.
  Vefring HK, Wee L, Jugessur A, Gjessing HK, Nilsen ST, Lie RT. Vefring HK, et al. BMC Med Genet. 2010 Jun 10;11:90. doi: 10.1186/1471-2350-11-90. BMC Med Genet. 2010. PMID: 20537141 Free PMC article.
• Mouse models of blood pressure regulation and hypertension.
  Sugiyama F, Yagami K, Paigen B. Sugiyama F, et al. Curr Hypertens Rep. 2001 Feb;3(1):41-8. doi: 10.1007/s11906-001-0077-8. Curr Hypertens Rep. 2001. PMID: 11177707 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)