Negative-strand RNA viruses: genetic engineering and applications - PubMed (original) (raw)

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Negative-strand RNA viruses: genetic engineering and applications

P Palese et al. Proc Natl Acad Sci U S A. 1996.

Abstract

The negative-strand RNA viruses are a broad group of animal viruses that comprise several important human pathogens, including influenza, measles, mumps, rabies, respiratory syncytial, Ebola, and hantaviruses. The development of new strategies to genetically manipulate the genomes of negative-strand RNA viruses has provided us with new tools to study the structure-function relationships of the viral components and their contributions to the pathogenicity of these viruses. It is also now possible to envision rational approaches--based on genetic engineering techniques--to design live attenuated vaccines against some of these viral agents. In addition, the use of different negative-strand RNA viruses as vectors to efficiently express foreign polypeptides has also become feasible, and these novel vectors have potential applications in disease prevention as well as in gene therapy.

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References

    1. J Virol. 1987 Dec;61(12):3809-19 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7415-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9558-62 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 May;87(10):3802-5 - PubMed
    1. J Virol. 1991 May;65(5):2711-3 - PubMed

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