GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination - PubMed (original) (raw)
GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination
W Liedtke et al. Neuron. 1996 Oct.
Free article
Abstract
To investigate the structural role of glial fibrillary acidic protein (GFAP) in vivo, mice carrying a null mutation in GFAP were generated. In 7/14 mutant animals older than 18 months of age, hydrocephalus associated with white matter loss was detected. Mutant mice displayed abnormal myelination including the presence of actively myelinating oligodendrocytes in adults, nonmyelinated axons in optic nerve, and reduced myelin thickness in spinal cord. White matter was poorly vascularized and the blood-brain barrier was structurally and functionally impaired. Astrocytic structure and function were abnormal, consisting of shortened astrocytic cell processes, decreased septation of white matter, and increased CNS extracellular space. Thus, GFAP expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination.
Similar articles
- Axonal and nonneuronal cell responses to spinal cord injury in mice lacking glial fibrillary acidic protein.
Wang X, Messing A, David S. Wang X, et al. Exp Neurol. 1997 Dec;148(2):568-76. doi: 10.1006/exnr.1997.6702. Exp Neurol. 1997. PMID: 9417833 - Rumpshaker: an X-linked mutation causing hypomyelination: developmental differences in myelination and glial cells between the optic nerve and spinal cord.
Fanarraga ML, Griffiths IR, McCulloch MC, Barrie JA, Kennedy PG, Brophy PJ. Fanarraga ML, et al. Glia. 1992;5(3):161-70. doi: 10.1002/glia.440050302. Glia. 1992. PMID: 1375190 - Expression of brain-specific hyaluronectin (BHN), a hyaluronate-binding protein, in dog postnatal development.
Bignami A, Dahl D. Bignami A, et al. Exp Neurol. 1988 Jan;99(1):107-17. doi: 10.1016/0014-4886(88)90131-8. Exp Neurol. 1988. PMID: 2446903 - Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).
Eng LF, Ghirnikar RS, Lee YL. Eng LF, et al. Neurochem Res. 2000 Oct;25(9-10):1439-51. doi: 10.1023/a:1007677003387. Neurochem Res. 2000. PMID: 11059815 Review. - AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology.
Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC. Saadoun S, et al. Neuroscience. 2009 Jul 7;161(3):764-72. doi: 10.1016/j.neuroscience.2009.03.069. Epub 2009 Apr 5. Neuroscience. 2009. PMID: 19345723 Review.
Cited by
- The role of astrocytes from synaptic to non-synaptic plasticity.
Sanz-Gálvez R, Falardeau D, Kolta A, Inglebert Y. Sanz-Gálvez R, et al. Front Cell Neurosci. 2024 Oct 18;18:1477985. doi: 10.3389/fncel.2024.1477985. eCollection 2024. Front Cell Neurosci. 2024. PMID: 39493508 Free PMC article. Review. - Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.
Zhao ST, Zhao L, Li JH. Zhao ST, et al. Neurochem Res. 2013 Mar;38(3):581-8. doi: 10.1007/s11064-012-0951-6. Epub 2013 Jan 1. Neurochem Res. 2013. PMID: 23277413 - Keratin nanoparticles-coating electrospun PVA nanofibers for potential neural tissue applications.
Guo T, Yang X, Deng J, Zhu L, Wang B, Hao S. Guo T, et al. J Mater Sci Mater Med. 2018 Dec 29;30(1):9. doi: 10.1007/s10856-018-6207-5. J Mater Sci Mater Med. 2018. PMID: 30594975 - Association of Very Early Serum Levels of S100B, Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and Spectrin Breakdown Product with Outcome in ProTECT III.
Frankel M, Fan L, Yeatts SD, Jeromin A, Vos PE, Wagner AK, Wolf BJ, Pauls Q, Lunney M, Merck LH, Hall CL, Palesch YY, Silbergleit R, Wright DW. Frankel M, et al. J Neurotrauma. 2019 Oct 15;36(20):2863-2871. doi: 10.1089/neu.2018.5809. Epub 2019 Jul 9. J Neurotrauma. 2019. PMID: 30794101 Free PMC article. Clinical Trial. - Circulating CD9+/GFAP+/survivin+ exosomes in malignant glioma patients following survivin vaccination.
Galbo PM Jr, Ciesielski MJ, Figel S, Maguire O, Qiu J, Wiltsie L, Minderman H, Fenstermaker RA. Galbo PM Jr, et al. Oncotarget. 2017 Oct 10;8(70):114722-114735. doi: 10.18632/oncotarget.21773. eCollection 2017 Dec 29. Oncotarget. 2017. PMID: 29383115 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous