High mutation frequencies among Escherichia coli and Salmonella pathogens - PubMed (original) (raw)
High mutation frequencies among Escherichia coli and Salmonella pathogens
J E LeClerc et al. Science. 1996.
Abstract
Here it is reported that the incidence of mutators among isolates of pathogenic Escherichia coli and Salmonella enterica is high (over 1 percent). These findings counter the theory, founded on studies with laboratory-attenuated strains, that suggests mutators are rare among bacterial populations. Defects in methyl-directed mismatch repair underlie all mutator phenotypes described here. Of nine independently derived hypermutable strains, seven contained a defective mutS allele. Because these mutant alleles increase the mutation rate and enhance recombination among diverse species, these studies may help explain both the rapid emergence of antibiotic resistance and the penetrance of virulence genes within the prokaryotic community.
Comment in
- Quick-change pathogens gain an evolutionary edge.
Grady D. Grady D. Science. 1996 Nov 15;274(5290):1081. doi: 10.1126/science.274.5290.1081. Science. 1996. PMID: 8966583 No abstract available. - Highly variable mutation rates in commensal and pathogenic Escherichia coli.
Matic I, Radman M, Taddei F, Picard B, Doit C, Bingen E, Denamur E, Elion J. Matic I, et al. Science. 1997 Sep 19;277(5333):1833-4. doi: 10.1126/science.277.5333.1833. Science. 1997. PMID: 9324769 No abstract available.
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