The outcome of the parasitic process initiated by Leishmania infantum in laboratory mice: a tissue-dependent pattern controlled by the Lsh and MHC loci - PubMed (original) (raw)
. 1996 Nov 15;157(10):4537-45.
Affiliations
- PMID: 8906832
The outcome of the parasitic process initiated by Leishmania infantum in laboratory mice: a tissue-dependent pattern controlled by the Lsh and MHC loci
V Leclercq et al. J Immunol. 1996.
Abstract
Human visceral leishmaniasis is mainly due to intracellular protozoan parasites of the Leishmania donovani complex, i.e., L. donovani and L. infantum (or L. chagasi). A mouse model has been established to monitor 1) the parasitic process initiated by L. infantum in three tissues they invade, and 2) parameters of the acquired immune response they trigger. Mice congenic at the Lsh locus and mice of inbred strains differing at the MHC locus have been inoculated by the i.v. route with L. infantum. The parasitic process has been evaluated by the follow-up of the parasitic load in the liver, the spleen, and, for the first time, in the bone marrow using a very sensitive limiting dilution assay. As previously established for L. donovani, the early outcome of L. infantum is also under the control of the Lsh locus in the liver; genes of the MHC complex are involved in the development of the subsequent acquired immune response. "Cure" or "noncure" haplotypes are the same for the two species of Leishmania; as far as the cure haplotype is concerned, whatever the tissues being screened, the parasites are never totally cleared, although the liver is the tissue in which the best parasite load reduction is achieved. Through immunostaining, it was established that sialoadhesin-positive stromal bone marrow macrophages contain parasites; such long-lived mononuclear phagocytes could be the host cells where the parasite can find "safe targets" unreactive to the dominant effector immune mechanism triggered by the replicative stage of the parasites.
Similar articles
- Infections in immunocompetent and immune-deficient mice with promastigotes of a North American isolate of Leishmania infantum.
Rosypal AC, Zajac AM, Troy GC, Lindsay DS. Rosypal AC, et al. Vet Parasitol. 2005 Jun 10;130(1-2):19-27. doi: 10.1016/j.vetpar.2005.03.017. Epub 2005 Apr 15. Vet Parasitol. 2005. PMID: 15893066 - Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.
Malo D, Vogan K, Vidal S, Hu J, Cellier M, Schurr E, Fuks A, Bumstead N, Morgan K, Gros P. Malo D, et al. Genomics. 1994 Sep 1;23(1):51-61. doi: 10.1006/geno.1994.1458. Genomics. 1994. PMID: 7829102 - Imprinting of BALB/c mice with low Leishmania infantum parasite dose markedly protects spleen against high-dose challenge.
Ferrua B, Luci C, Le Fichoux Y, Paul A, Marty P. Ferrua B, et al. Vaccine. 2006 Jan 30;24(5):589-96. doi: 10.1016/j.vaccine.2005.08.057. Epub 2005 Aug 29. Vaccine. 2006. PMID: 16157427 - Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?
McMahon-Pratt D, Alexander J. McMahon-Pratt D, et al. Immunol Rev. 2004 Oct;201:206-24. doi: 10.1111/j.0105-2896.2004.00190.x. Immunol Rev. 2004. PMID: 15361243 Review. - Systemic and compartmentalized immune response in canine visceral leishmaniasis.
Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Giunchetti RC, Carneiro CM, Mayrink W, Tafuri WL, Corrêa-Oliveira R. Reis AB, et al. Vet Immunol Immunopathol. 2009 Mar 15;128(1-3):87-95. doi: 10.1016/j.vetimm.2008.10.307. Epub 2008 Oct 17. Vet Immunol Immunopathol. 2009. PMID: 19054576 Review.
Cited by
- Leishmania donovani infection suppresses Allograft Inflammatory Factor-1 in monocytes and macrophages to inhibit inflammatory responses.
da Silva RL, Elizondo DM, Brandy NZD, Haddock NL, Boddie TA, de Oliveira LL, de Jesus AR, de Almeida RP, de Moura TR, Lipscomb MW. da Silva RL, et al. Sci Rep. 2021 Jan 13;11(1):946. doi: 10.1038/s41598-020-79068-6. Sci Rep. 2021. PMID: 33441583 Free PMC article. - Novel Loci Controlling Parasite Load in Organs of Mice Infected With Leishmania major, Their Interactions and Sex Influence.
Kobets T, Čepičková M, Volkova V, Sohrabi Y, Havelková H, Svobodová M, Demant P, Lipoldová M. Kobets T, et al. Front Immunol. 2019 Jun 7;10:1083. doi: 10.3389/fimmu.2019.01083. eCollection 2019. Front Immunol. 2019. PMID: 31231359 Free PMC article. - Histopathological and immunohistochemical characterisation of hepatic granulomas in Leishmania donovani-infected BALB/c mice: a time-course study.
Salguero FJ, Garcia-Jimenez WL, Lima I, Seifert K. Salguero FJ, et al. Parasit Vectors. 2018 Jan 31;11(1):73. doi: 10.1186/s13071-018-2624-z. Parasit Vectors. 2018. PMID: 29386047 Free PMC article. - New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence.
Melo GD, Goyard S, Lecoeur H, Rouault E, Pescher P, Fiette L, Boissonnas A, Minoprio P, Lang T. Melo GD, et al. PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005924. doi: 10.1371/journal.pntd.0005924. eCollection 2017 Sep. PLoS Negl Trop Dis. 2017. PMID: 28945751 Free PMC article. - Redundant and regulatory roles for Toll-like receptors in Leishmania infection.
Chauhan P, Shukla D, Chattopadhyay D, Saha B. Chauhan P, et al. Clin Exp Immunol. 2017 Nov;190(2):167-186. doi: 10.1111/cei.13014. Epub 2017 Aug 7. Clin Exp Immunol. 2017. PMID: 28708252 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases
Research Materials