Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation - PubMed (original) (raw)

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Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation

C C Conaway et al. Pharmacol Ther. 1996.

Abstract

Exposures of rodents to airborne formaldehyde (FA) produce dose-related toxicity, enhanced cell proliferation and squamous cell carcinomas in the nasal passages. The mechanism of FA-induced tumor formation involves DNA-protein crosslink formation and enhanced cell proliferation secondarily to cytotoxicity. The mucociliary apparatus and glutathione protect against low-dose FA-induced effects. Consequently, the mechanistic information is consistent with a very sublinear dose-response curve for tumor formation. The sublinear dose-response of nasal DNA-protein crosslinks levels in rodents and monkeys has been used in the risk assessment of FA.

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