T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis - PubMed (original) (raw)
Case Reports
. 1996 Nov 1;184(5):1791-800.
doi: 10.1084/jem.184.5.1791.
J David-Ameline, M A Peyrat, A Moreau-Aubry, D Pinczon, A Lim, J Even, G Semana, J M Berthelot, R Breathnach, M Bonneville, E Houssaint
Affiliations
- PMID: 8920867
- PMCID: PMC2192863
- DOI: 10.1084/jem.184.5.1791
Case Reports
T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis
E Scotet et al. J Exp Med. 1996.
Abstract
Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.
Similar articles
- Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response.
Steven NM, Annels NE, Kumar A, Leese AM, Kurilla MG, Rickinson AB. Steven NM, et al. J Exp Med. 1997 May 5;185(9):1605-17. doi: 10.1084/jem.185.9.1605. J Exp Med. 1997. PMID: 9151898 Free PMC article. - Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes.
Scotet E, Peyrat MA, Saulquin X, Retiere C, Couedel C, Davodeau F, Dulphy N, Toubert A, Bignon JD, Lim A, Vie H, Hallet MM, Liblau R, Weber M, Berthelot JM, Houssaint E, Bonneville M. Scotet E, et al. Eur J Immunol. 1999 Mar;29(3):973-85. doi: 10.1002/(SICI)1521-4141(199903)29:03<973::AID-IMMU973>3.0.CO;2-P. Eur J Immunol. 1999. PMID: 10092102 - Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen.
Fox R, Sportsman R, Rhodes G, Luka J, Pearson G, Vaughan J. Fox R, et al. J Clin Invest. 1986 May;77(5):1539-47. doi: 10.1172/JCI112469. J Clin Invest. 1986. PMID: 2422209 Free PMC article. - Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis.
Trier N, Izarzugaza J, Chailyan A, Marcatili P, Houen G. Trier N, et al. Int J Mol Sci. 2018 Jan 21;19(1):317. doi: 10.3390/ijms19010317. Int J Mol Sci. 2018. PMID: 29361739 Free PMC article. Review. - Epstein-Barr virus and rheumatoid arthritis.
Balandraud N, Roudier J, Roudier C. Balandraud N, et al. Autoimmun Rev. 2004 Jul;3(5):362-7. doi: 10.1016/j.autrev.2004.02.002. Autoimmun Rev. 2004. PMID: 15288002 Review.
Cited by
- Selection of Epstein-Barr virus specific cytotoxic T lymphocytes can be performed with B lymphoblastoid cell lines created in serum-free media.
Gallot G, Vollant S, Vivien R, Clémenceau B, Ferrand C, Tiberghien P, Gaschet J, Robillard N, Vié H. Gallot G, et al. Clin Exp Immunol. 2006 Apr;144(1):158-68. doi: 10.1111/j.1365-2249.2006.03035.x. Clin Exp Immunol. 2006. PMID: 16542378 Free PMC article. - Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.
Misko IS, Cross SM, Khanna R, Elliott SL, Schmidt C, Pye SJ, Silins SL. Misko IS, et al. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2279-84. doi: 10.1073/pnas.96.5.2279. Proc Natl Acad Sci U S A. 1999. PMID: 10051632 Free PMC article. - Epstein-Barr virus and rheumatoid arthritis: is there a link?
Costenbader KH, Karlson EW. Costenbader KH, et al. Arthritis Res Ther. 2006;8(1):204. doi: 10.1186/ar1893. Epub 2006 Jan 16. Arthritis Res Ther. 2006. PMID: 16542469 Free PMC article. Review. - CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells.
Pudney VA, Leese AM, Rickinson AB, Hislop AD. Pudney VA, et al. J Exp Med. 2005 Feb 7;201(3):349-60. doi: 10.1084/jem.20041542. Epub 2005 Jan 31. J Exp Med. 2005. PMID: 15684323 Free PMC article. - Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis.
Ball RJ, Avenell A, Aucott L, Hanlon P, Vickers MA. Ball RJ, et al. Arthritis Res Ther. 2015 Sep 29;17:274. doi: 10.1186/s13075-015-0755-6. Arthritis Res Ther. 2015. PMID: 26416719 Free PMC article. Review.
References
- J Exp Med. 1990 Mar 1;171(3):831-41 - PubMed
- J Exp Med. 1996 Mar 1;183(3):1215-28 - PubMed
- N Engl J Med. 1975 Sep 11;293(11):517-20 - PubMed
- Arthritis Rheum. 1977 Jun;20(5):1037-42 - PubMed
- N Engl J Med. 1978 Apr 20;298(16):869-71 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical