Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs - PubMed (original) (raw)
Comparative Study
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs
P D Rennert et al. J Exp Med. 1996.
Abstract
For more than a decade, the biological roles and the apparent redundancy of the cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) have been debated. LT alpha exists in its soluble form as a homotrimer, which like TNF only binds the TNF receptors, TNF-R55 or TNF-R75. The cell surface form of LT exists as a heteromer of LT alpha and LT beta subunits and this complex specifically binds the LT beta receptor (LT beta-R). To discriminate the functions of the LT and TNF systems, soluble LT beta-R-immunoglobulin (Ig) or TNF-R-Ig fusion proteins were introduced into embryonic circulation by injecting pregnant mice. Exposure to LT beta-R-Ig during gestation disrupted lymph node development and splenic architecture in the progeny indicating that both effects are mediated by the surface LT alpha/beta complex. These data are the first to identify a cell surface ligand involved in immune organ morphogenesis. Moreover, they unambiguously discriminate the functions of the various TNF/LT ligands, provide a unique model to study compartmentalization of immune responses and illustrate the generic utility of receptor-Ig fusion proteins for dissecting/ordering ontogenetic events in the absence of genetic modifications.
Similar articles
- Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization.
Rennert PD, Browning JL, Hochman PS. Rennert PD, et al. Int Immunol. 1997 Nov;9(11):1627-39. doi: 10.1093/intimm/9.11.1627. Int Immunol. 1997. PMID: 9418124 - Peyer's patch organogenesis--cytokines rule, OK?
Mayrhofer G. Mayrhofer G. Gut. 1997 Nov;41(5):707-9. doi: 10.1136/gut.41.5.707. Gut. 1997. PMID: 9414984 Free PMC article. Review. - Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein.
Ettinger R, Browning JL, Michie SA, van Ewijk W, McDevitt HO. Ettinger R, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13102-7. doi: 10.1073/pnas.93.23.13102. Proc Natl Acad Sci U S A. 1996. PMID: 8917551 Free PMC article. - Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development.
Ettinger R, Mebius R, Browning JL, Michie SA, van Tuijl S, Kraal G, van Ewijk W, McDevitt HO. Ettinger R, et al. Int Immunol. 1998 Jun;10(6):727-41. doi: 10.1093/intimm/10.6.727. Int Immunol. 1998. PMID: 9678753 - Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
Matsumoto M. Matsumoto M. J Med Invest. 1999 Aug;46(3-4):141-50. J Med Invest. 1999. PMID: 10687308 Review.
Cited by
- HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme.
Yang X, Jiang S, Liu F, Li Z, Liu W, Zhang X, Nan F, Li J, Yu M, Wang Y, Wang B. Yang X, et al. Mol Neurobiol. 2024 Aug;61(8):5935-5949. doi: 10.1007/s12035-024-03937-8. Epub 2024 Jan 23. Mol Neurobiol. 2024. PMID: 38261253 Free PMC article. - Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells.
Arroz-Madeira S, Bekkhus T, Ulvmar MH, Petrova TV. Arroz-Madeira S, et al. Circ Res. 2023 Apr 28;132(9):1203-1225. doi: 10.1161/CIRCRESAHA.123.322136. Epub 2023 Apr 27. Circ Res. 2023. PMID: 37104555 Free PMC article. Review. - Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice.
Cheong LY, Wang B, Wang Q, Jin L, Kwok KHM, Wu X, Shu L, Lin H, Chung SK, Cheng KKY, Hoo RLC, Xu A. Cheong LY, et al. Nat Commun. 2023 Mar 3;14(1):1213. doi: 10.1038/s41467-023-36737-0. Nat Commun. 2023. PMID: 36869026 Free PMC article. - Micro- and Macro-Anatomical Frameworks of Lymph Nodes Indispensable for the Lymphatic System Filtering Function.
Ozawa M, Nakajima S, Kobayashi D, Tomii K, Li NJ, Watarai T, Suzuki R, Watanabe S, Kanda Y, Takeuchi A, Katakai T. Ozawa M, et al. Front Cell Dev Biol. 2022 Jun 20;10:902601. doi: 10.3389/fcell.2022.902601. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35794860 Free PMC article. - Gene expression in lung epithelial cells following interaction with Pneumocystis carinii and its specific life forms yields insights into host gene responses to infection.
Kottom TJ, Carmona EM, Limper AH. Kottom TJ, et al. Microbiol Immunol. 2022 May;66(5):238-251. doi: 10.1111/1348-0421.12972. Epub 2022 Mar 31. Microbiol Immunol. 2022. PMID: 35229348 Free PMC article.
References
- J Immunol. 1993 Dec 1;151(11):6076-88 - PubMed
- J Exp Med. 1996 Jul 1;184(1):259-64 - PubMed
- Eur J Immunol. 1996 Mar;26(3):669-75 - PubMed
- J Immunol. 1996 Feb 15;156(4):1587-93 - PubMed
- Eur J Immunol. 1994 Feb;24(2):429-34 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources