Ran, a GTPase involved in nuclear processes: its regulators and effectors - PubMed (original) (raw)
Review
. 1996 Oct:109 ( Pt 10):2423-7.
doi: 10.1242/jcs.109.10.2423.
Affiliations
- PMID: 8923203
- DOI: 10.1242/jcs.109.10.2423
Review
Ran, a GTPase involved in nuclear processes: its regulators and effectors
J M Avis et al. J Cell Sci. 1996 Oct.
Abstract
Ran is a small GTPase that has been implicated in a variety of nuclear processes, including the maintainance of nuclear structure, protein import, mRNA processing and export, and cell cycle regulation. There has been significant progress in determining the role of Ran in nuclear protein import. However, it has been unclear whether this role is sufficient to account for the diverse effects of disrupting Ran functions. Recently, several proteins have been identified that bind specifically to Ran and are, therefore, possible effectors. Other experiments using dominant mutants of Ran that block its GTP/GDP cycle have suggested that Ran may have multiple roles. Here, these results are summarised and discussed with respect to the action of Ran.
Similar articles
- A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.
Murphy GA, Moore MS, Drivas G, Pérez de la Ossa P, Villamarin A, D'Eustachio P, Rush MG. Murphy GA, et al. Mol Biol Cell. 1997 Dec;8(12):2591-604. doi: 10.1091/mbc.8.12.2591. Mol Biol Cell. 1997. PMID: 9398678 Free PMC article. - Functions of the GTPase Ran in RNA export from the nucleus.
Dahlberg JE, Lund E. Dahlberg JE, et al. Curr Opin Cell Biol. 1998 Jun;10(3):400-8. doi: 10.1016/s0955-0674(98)80017-3. Curr Opin Cell Biol. 1998. PMID: 9640542 Review. - Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.
Ren M, Villamarin A, Shih A, Coutavas E, Moore MS, LoCurcio M, Clarke V, Oppenheim JD, D'Eustachio P, Rush MG. Ren M, et al. Mol Cell Biol. 1995 Apr;15(4):2117-24. doi: 10.1128/MCB.15.4.2117. Mol Cell Biol. 1995. PMID: 7891706 Free PMC article. - The role of the Ran GTPase pathway in cell cycle control and interphase nuclear functions.
Dasso M. Dasso M. Prog Cell Cycle Res. 1995;1:163-72. doi: 10.1007/978-1-4615-1809-9_13. Prog Cell Cycle Res. 1995. PMID: 9552361 Review. - RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import.
Chi NC, Adam EJ, Visser GD, Adam SA. Chi NC, et al. J Cell Biol. 1996 Nov;135(3):559-69. doi: 10.1083/jcb.135.3.559. J Cell Biol. 1996. PMID: 8909533 Free PMC article.
Cited by
- Hydrogen peroxide inhibition of nuclear protein import is mediated by the mitogen-activated protein kinase, ERK2.
Czubryt MP, Austria JA, Pierce GN. Czubryt MP, et al. J Cell Biol. 2000 Jan 10;148(1):7-16. doi: 10.1083/jcb.148.1.7. J Cell Biol. 2000. PMID: 10629214 Free PMC article. - E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging.
Ramón-Landreau M, Sánchez-Puelles C, López-Sánchez N, Lozano-Ureña A, Llabrés-Mas AM, Frade JM. Ramón-Landreau M, et al. Int J Mol Sci. 2022 Oct 11;23(20):12093. doi: 10.3390/ijms232012093. Int J Mol Sci. 2022. PMID: 36292945 Free PMC article. Review. - The small GTPase Gsp1p binds to the repeat domain of the nucleoporin Nsp1p.
Stochaj U, Héjazi M, Belhumeur P. Stochaj U, et al. Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):421-7. doi: 10.1042/bj3300421. Biochem J. 1998. PMID: 9461539 Free PMC article. - Gene expression of benthic amphipods (genus: Diporeia) in relation to a circular ssDNA virus across two Laurentian Great Lakes.
Bistolas KSI, Rudstam LG, Hewson I. Bistolas KSI, et al. PeerJ. 2017 Sep 26;5:e3810. doi: 10.7717/peerj.3810. eCollection 2017. PeerJ. 2017. PMID: 28966890 Free PMC article. - Single-cell alternative polyadenylation analysis delineates GABAergic neuron types.
Yang Y, Paul A, Bach TN, Huang ZJ, Zhang MQ. Yang Y, et al. BMC Biol. 2021 Jul 23;19(1):144. doi: 10.1186/s12915-021-01076-3. BMC Biol. 2021. PMID: 34301239 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous