The role of protein degradation in mitochondrial function and biogenesis - PubMed (original) (raw)
Review
The role of protein degradation in mitochondrial function and biogenesis
M Rep et al. Curr Genet. 1996 Nov.
Abstract
It has been known for a long time that mitochondria contain their own protein-degradation systems. Only recently, however, have genes for mitochondrial proteases been identified and the powerful techniques of molecular biology been applied to gain insight into the role of protein degradation in mitochondrial biogenesis. It is now clear that the mitochondrial proteases that are involved in the initial stages of degradation are similar to prokaryotic ATP-dependent proteases, and that a division of labour exists between soluble and membrane-bound systems. These systems are essential for the biogenesis of fully functional mitochondria. Their natural targets are currently being identified, and their co-operation with chaperones and possible dual functions as chaperones/proteases are being investigated.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources