Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling - PubMed (original) (raw)

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

M Givskov et al. J Bacteriol. 1996 Nov.

Abstract

Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.

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