Production of interleukin-1 by polymorphonuclear leukocytes resident in periradicular tissue - PubMed (original) (raw)
Production of interleukin-1 by polymorphonuclear leukocytes resident in periradicular tissue
G A Miller et al. J Endod. 1996 Jul.
Abstract
Twenty-one patients undergoing endodontic surgery were identified. Periradicular tissue samples were recovered, and those showing significant numbers of polymorphonuclear leukocyte (PMN) infiltration were prepared for immunoperoxidase identification of interleukin (IL)-1 alpha and IL-1 beta-producing cells using specific polyclonal antibodies. In selected tissue specimens, 90% or more of the PMN's were found to stain positively for IL-1 alpha and IL-1 beta. In addition, significant numbers of plasma cells and tissue histiocytes stained positively for these IL's. Cell suspensions from selected periapical granuloma specimens, as well as from purified peripheral blood PMN's and peripheral blood mononuclear cells, were also subjected to IL-1 quantitation using a commercial ELISA procedure. Such cell suspensions were found to produce significant levels of IL and could be stimulated to produce increased levels after coculture with lipopolysaccharide. These results suggest that PMN's in inflammatory periradicular tissues may be a significant source of IL-1, and their possible roles in the establishment and resolution of periradicular lesions need to be re-evaluated.
Similar articles
- Interleukin-6 in neutrophils from peripheral blood and inflammatory periradicular tissues.
Euler GJ, Miller GA, Hutter JW, D'Alesandro MM. Euler GJ, et al. J Endod. 1998 Jul;24(7):480-4. doi: 10.1016/S0099-2399(98)80051-4. J Endod. 1998. PMID: 9693575 - T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas.
Marçal JR, Samuel RO, Fernandes D, de Araujo MS, Napimoga MH, Pereira SA, Clemente-Napimoga JT, Alves PM, Mattar R, Rodrigues V Jr, Rodrigues DB. Marçal JR, et al. J Endod. 2010 Jun;36(6):995-9. doi: 10.1016/j.joen.2010.03.020. J Endod. 2010. PMID: 20478453 - Immunoexpression of interleukin 17 in apical periodontitis lesions.
Ajuz NC, Antunes H, Mendonça TA, Pires FR, Siqueira JF Jr, Armada L. Ajuz NC, et al. J Endod. 2014 Sep;40(9):1400-3. doi: 10.1016/j.joen.2014.03.024. Epub 2014 Jul 16. J Endod. 2014. PMID: 25043329 - Periradicular curettage.
Lin LM, Gaengler P, Langeland K. Lin LM, et al. Int Endod J. 1996 Jul;29(4):220-7. doi: 10.1111/j.1365-2591.1996.tb01373.x. Int Endod J. 1996. PMID: 9206437 Review. - Microbiological, pathological, inflammatory, immunological and molecular biological aspects of periradicular disease.
Takahashi K. Takahashi K. Int Endod J. 1998 Sep;31(5):311-25. doi: 10.1046/j.1365-2591.1998.00171.x. Int Endod J. 1998. PMID: 9823133 Review.
Cited by
- The relationship between self-reported history of endodontic therapy and coronary heart disease in the Atherosclerosis Risk in Communities Study.
Caplan DJ, Pankow JS, Cai J, Offenbacher S, Beck JD. Caplan DJ, et al. J Am Dent Assoc. 2009 Aug;140(8):1004-12. doi: 10.14219/jada.archive.2009.0311. J Am Dent Assoc. 2009. PMID: 19654253 Free PMC article. - Pathogenesis of apical periodontitis: a literature review.
Graunaite I, Lodiene G, Maciulskiene V. Graunaite I, et al. J Oral Maxillofac Res. 2012 Jan 1;2(4):e1. doi: 10.5037/jomr.2011.2401. J Oral Maxillofac Res. 2012. PMID: 24421998 Free PMC article. Review. - Lesions of endodontic origin and risk of coronary heart disease.
Caplan DJ, Chasen JB, Krall EA, Cai J, Kang S, Garcia RI, Offenbacher S, Beck JD. Caplan DJ, et al. J Dent Res. 2006 Nov;85(11):996-1000. doi: 10.1177/154405910608501104. J Dent Res. 2006. PMID: 17062738 Free PMC article. - The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.
Rios Osorio N, Caviedes-Bucheli J, Mosquera-Guevara L, Adames-Martinez JS, Gomez-Pinto D, Jimenez-Jimenez K, Avendano Maz H, Bornacelly-Mendoza S. Rios Osorio N, et al. Eur Endod J. 2023 Jan;8(1):20-36. doi: 10.14744/eej.2022.26918. Eur Endod J. 2023. PMID: 36748442 Free PMC article. Review. - Revisiting the role of IL-1 signaling in the development of apical periodontitis.
Tazawa K, Azuma Presse MM, Furusho H, Stashenko P, Sasaki H. Tazawa K, et al. Front Dent Med. 2022;3:985558. doi: 10.3389/fdmed.2022.985558. Epub 2022 Aug 11. Front Dent Med. 2022. PMID: 36938490 Free PMC article.