Codon usage in the Mycobacterium tuberculosis complex - PubMed (original) (raw)
Comparative Study
. 1996 Apr:142 ( Pt 4):915-925.
doi: 10.1099/00221287-142-4-915.
Affiliations
- PMID: 8936318
- DOI: 10.1099/00221287-142-4-915
Free article
Comparative Study
Codon usage in the Mycobacterium tuberculosis complex
Siv G E Andersson et al. Microbiology (Reading). 1996 Apr.
Free article
Abstract
The usage of alternative synonymous codons in Mycobacterium tuberculosis (and M. bovis) genes has been investigated. This species is a member of the high-G+C Gram-positive bacteria, with a genomic G+C content around 65 mol%. This G+C-richness is reflected in a strong bias towards C- and G-ending codons for every amino acid: overall, the G+C content at the third positions of codons is 83%. However, there is significant variation in codon usage patterns among genes, which appears to be associated with gene expression level. From the variation among genes, putative optimal codons were identified for 15 amino acids. The degree of bias towards optimal codons in an M. tuberculosis gene is correlated with that in homologues from Escherichia coli and Bacillus subtilis. The set of selectively favoured codons seems to be quite highly conserved between M. tuberculosis and another high-G+C Gram-positive bacterium, Corynebacterium glutamicum, even though the genome and overall codon usage of the latter are much less G+C-rich.
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