To stick or not to stick: the new leukocyte homing paradigm - PubMed (original) (raw)
Review
To stick or not to stick: the new leukocyte homing paradigm
D Dunon et al. Curr Opin Cell Biol. 1996 Oct.
Abstract
The immune system is formed by leukocytes. They are passively transported through the body by the vascular system, but their entrance into tissues requires a coordinated series of events, namely activation of leukocyte integrins, adhesion to the vascular endothelium, and migration. There are four steps in this process, which begin with the rolling of leukocytes along the vascular endothelium, followed by signaling which activates leukocyte integrins, thus leading to tight adhesion to the endothelium and finally transmigration. Substantial progress has been made recently in elucidating the molecular events that induce rolling and signaling, partly as a result of the study of double-knockout mice that are deficient for genes encoding two selectins.
Similar articles
- Selectin avidity modulation by chemokines at subsecond endothelial contacts: a novel regulatory level of leukocyte trafficking.
Dwir O, Grabovsky V, Alon R. Dwir O, et al. Ernst Schering Res Found Workshop. 2004;(44):109-35. doi: 10.1007/978-3-662-05397-3_7. Ernst Schering Res Found Workshop. 2004. PMID: 14579777 Review. No abstract available. - Chemokines in rapid leukocyte adhesion triggering and migration.
Johnston B, Butcher EC. Johnston B, et al. Semin Immunol. 2002 Apr;14(2):83-92. doi: 10.1006/smim.2001.0345. Semin Immunol. 2002. PMID: 11978080 Review. - Physiology and pathophysiology of selectins, integrins, and IgSF cell adhesion molecules focusing on inflammation. A paradigm model on infectious endocarditis.
Golias C, Batistatou A, Bablekos G, Charalabopoulos A, Peschos D, Mitsopoulos P, Charalabopoulos K. Golias C, et al. Cell Commun Adhes. 2011 Jun;18(3):19-32. doi: 10.3109/15419061.2011.606381. Epub 2011 Sep 5. Cell Commun Adhes. 2011. PMID: 21892874 Review. - The selectins: insights into selectin-induced intracellular signaling in leukocytes.
Crockett-Torabi E, Fantone JC. Crockett-Torabi E, et al. Immunol Res. 1995;14(4):237-51. doi: 10.1007/BF02935622. Immunol Res. 1995. PMID: 8722041 Review. - The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver.
Li Y, Muruve DA, Collins RG, Lee SS, Kubes P. Li Y, et al. Eur J Immunol. 2002 Dec;32(12):3443-52. doi: 10.1002/1521-4141(200212)32:12<3443::AID-IMMU3443>3.0.CO;2-F. Eur J Immunol. 2002. PMID: 12442326
Cited by
- Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration.
Locard-Paulet M, Lim L, Veluscek G, McMahon K, Sinclair J, van Weverwijk A, Worboys JD, Yuan Y, Isacke CM, Jørgensen C. Locard-Paulet M, et al. Sci Signal. 2016 Feb 9;9(414):ra15. doi: 10.1126/scisignal.aac5820. Sci Signal. 2016. PMID: 26861043 Free PMC article. - The role of platelets in the recruitment of leukocytes during vascular disease.
Ed Rainger G, Chimen M, Harrison MJ, Yates CM, Harrison P, Watson SP, Lordkipanidzé M, Nash GB. Ed Rainger G, et al. Platelets. 2015;26(6):507-20. doi: 10.3109/09537104.2015.1064881. Epub 2015 Jul 21. Platelets. 2015. PMID: 26196409 Free PMC article. Review. - Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites.
Tang J, Zarbock A, Gomez I, Wilson CL, Lefort CT, Stadtmann A, Bell B, Huang LC, Ley K, Raines EW. Tang J, et al. Blood. 2011 Jul 21;118(3):786-94. doi: 10.1182/blood-2010-11-321406. Epub 2011 May 31. Blood. 2011. PMID: 21628404 Free PMC article. - Eph-ephrin bidirectional signaling comes into the context of lymphocyte transendothelial migration.
Trinidad EM, Zapata AG, Alonso-Colmenar LM. Trinidad EM, et al. Cell Adh Migr. 2010 Jul-Sep;4(3):363-7. doi: 10.4161/cam.4.3.11586. Epub 2010 Jul 22. Cell Adh Migr. 2010. PMID: 20400865 Free PMC article. - Monocytes in atherosclerosis: subsets and functions.
Woollard KJ, Geissmann F. Woollard KJ, et al. Nat Rev Cardiol. 2010 Feb;7(2):77-86. doi: 10.1038/nrcardio.2009.228. Epub 2010 Jan 12. Nat Rev Cardiol. 2010. PMID: 20065951 Free PMC article. Review.