Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions - PubMed (original) (raw)
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Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions
J E Ladbury et al. Chem Biol. 1996 Oct.
Abstract
Biomolecular interactions can be defined by combining thermodynamic data on the energetic properties of the interaction with high-resolution structural data. The development of high sensitivity isothermal titration calorimetric equipment provides a dramatic advance in the gathering of thermodynamic data, and the interactions between biological macromolecules can now be described with unprecedented accuracy.
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