Sex-specific assembly of a dosage compensation complex on the nematode X chromosome - PubMed (original) (raw)
Sex-specific assembly of a dosage compensation complex on the nematode X chromosome
P T Chuang et al. Science. 1996.
Abstract
In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.
Comment in
- Promiscuous chromosomal proteins: complexes about sex.
Kuroda MI, Villeneuve AM. Kuroda MI, et al. Science. 1996 Dec 6;274(5293):1633-4. doi: 10.1126/science.274.5293.1633. Science. 1996. PMID: 8984631 No abstract available.
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