Epstein-Barr virus and human T-cell lymphomas - PubMed (original) (raw)
Epstein-Barr virus and human T-cell lymphomas
C J Meijer et al. Semin Cancer Biol. 1996 Aug.
Abstract
Epstein-Barr virus has been classically associated with certain B-lymphocytic benign and malignant proliferations. However, using molecular biological techniques it becomes clear that EBV is also associated with several T-NHL in non-immunocompromised patients. The distribution of EBV-associated T-NHL seems to be site-restricted, i.e. in about 100% of the nasal T-NHL and in 20% of the lung and gastrointestinal lymphomas and rarely in primary cutaneous T-cell lymphomas. Moreover, the expression of the LMP1 protein seems to be associated with a poor prognosis. In this section the role of EBV in the pathogenesis of T-NHL will be discussed.
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