Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion? - PubMed (original) (raw)
Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?
S Strand et al. Nat Med. 1996 Dec.
Abstract
The CD95 (APO-1/Fas) system is an important mediator of T-cell cytotoxicity. We investigated this system in 22 hepatocellular carcinomas (HCCs) from patients. All HCCs had partially or completely lost the expression of the CD95 receptor constitutively expressed by normal liver cells and might thus evade CD95-mediated killing. We also considered a new mechanism of immune evasion, namely, the active destruction of T-lymphocytes by tumor cells expressing CD95 ligand (CD95L). CD95L messenger RNA and protein could be detected in the HCCs. In coculture experiments, HepG2 hepatoblastoma cells, expressing CD95L mRNA after treatment with cytostatic drugs, killed CD95+ Jurkat lymphocytes. Our data suggest that tumor cells can evade immune attack by down-regulation of the CD95 receptor and killing of lymphocytes through expression of CD95L.
Comment in
- Fas ligand and immune evasion.
Nagata S. Nagata S. Nat Med. 1996 Dec;2(12):1306-7. doi: 10.1038/nm1296-1306. Nat Med. 1996. PMID: 8946823 No abstract available. - Tumor cells induce apoptosis in lymphocytes.
Rubio CA. Rubio CA. Nat Med. 1997 Mar;3(3):253-4. doi: 10.1038/nm0397-253b. Nat Med. 1997. PMID: 9055844 No abstract available.
Similar articles
- Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.
Müller M, Strand S, Hug H, Heinemann EM, Walczak H, Hofmann WJ, Stremmel W, Krammer PH, Galle PR. Müller M, et al. J Clin Invest. 1997 Feb 1;99(3):403-13. doi: 10.1172/JCI119174. J Clin Invest. 1997. PMID: 9022073 Free PMC article. - CD95 ligand expression as a mechanism of immune escape in breast cancer.
Müschen M, Moers C, Warskulat U, Even J, Niederacher D, Beckmann MW. Müschen M, et al. Immunology. 2000 Jan;99(1):69-77. doi: 10.1046/j.1365-2567.2000.00921.x. Immunology. 2000. PMID: 10651943 Free PMC article. - Differential and mutually exclusive expression of CD95 and CD95 ligand in epithelia of normal pancreas and chronic pancreatitis.
Hasel C, Rau B, Perner S, Sträter J, Möller P. Hasel C, et al. Lab Invest. 2001 Mar;81(3):317-26. doi: 10.1038/labinvest.3780240. Lab Invest. 2001. PMID: 11310825 - On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model.
Greil R, Egle A, Villunger A. Greil R, et al. Leuk Lymphoma. 1998 Nov;31(5-6):477-90. doi: 10.3109/10428199809057607. Leuk Lymphoma. 1998. PMID: 9922038 Review. - Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system.
Li-Weber M, Krammer PH. Li-Weber M, et al. Semin Immunol. 2003 Jun;15(3):145-57. doi: 10.1016/s1044-5323(03)00030-7. Semin Immunol. 2003. PMID: 14563113 Review.
Cited by
- Identification of patients at risk for early death after conventional chemotherapy in solid tumours and lymphomas.
Ray-Coquard I, Ghesquière H, Bachelot T, Borg C, Biron P, Sebban C, LeCesne A, Chauvin F, Blay JY; ELYPSE Study Group. Ray-Coquard I, et al. Br J Cancer. 2001 Sep 14;85(6):816-22. doi: 10.1054/bjoc.2001.2011. Br J Cancer. 2001. PMID: 11556830 Free PMC article. - Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma.
Lerma E, Romero M, Gallardo A, Pons C, Muñoz J, Fuentes J, Lloveras B, Catasus L, Prat J. Lerma E, et al. Virchows Arch. 2008 Jan;452(1):65-74. doi: 10.1007/s00428-007-0535-z. Epub 2007 Nov 14. Virchows Arch. 2008. PMID: 18000680 - Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL.
Biswas RS, Cha HJ, Hardwick JM, Srivastava RK. Biswas RS, et al. Mol Cell Biochem. 2001 Sep;225(1-):7-20. doi: 10.1023/a:1012203110027. Mol Cell Biochem. 2001. PMID: 11716366 - Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation.
Suhara T, Kim HS, Kirshenbaum LA, Walsh K. Suhara T, et al. Mol Cell Biol. 2002 Jan;22(2):680-91. doi: 10.1128/MCB.22.2.680-691.2002. Mol Cell Biol. 2002. PMID: 11756562 Free PMC article. - Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.
Fingleton B, Vargo-Gogola T, Crawford HC, Matrisian LM. Fingleton B, et al. Neoplasia. 2001 Nov-Dec;3(6):459-68. doi: 10.1038/sj.neo.7900190. Neoplasia. 2001. PMID: 11774028 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous