Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases - PubMed (original) (raw)
Review
Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases
A Harada et al. Mol Med Today. 1996 Nov.
Abstract
Aberrant production of interleukin 8 (IL-8) has been shown in various human inflammatory diseases. Recent investigations in animal models using either blocking antibodies against IL-8 or disruption of the gene encoding the IL-8 receptor have revealed the involvement of IL-8 in the recruitment of neutrophils and in neutrophil-associated tissue injury in acute inflammation. These studies suggest that IL-8 is a novel target to alleviate acute inflammation. This review describes the properties of IL-8 and discusses different therapeutic approaches to target IL-8, particularly the use of humanized monoclonal antibodies against IL-8 and inhibition of IL-8 gene transcription.
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