Oral glucose-tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehall survey - PubMed (original) (raw)
Oral glucose-tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehall survey
H A Sayegh et al. Lancet. 1979.
Abstract
Men who participated in the Whitehall survey and were found to be glucose intolerant have been studied 6--8 years later, together with a control group of men with normal screening blood-sugar levels. Ophthalmoscopically visible microvascular retinal disease was confined to men diagnosed as probably diabetic after the survey because their 2 h blood-sugar level (after a 50 g oral glucose load) in the survey examination or during a subsequent standard oral glucose-tolerance test was greater than or equal to 200 mg/dl (11.1 mmol/l). The lowest blood-sugar in a "diabetic" subsequently found to have retinopathy was 229 mg/dl. Men with lesser degrees of glucose intolerance, including 34 who had "worsened to diabetes", did not have visible retinovascular disease at follow-up. If diabetes implies a risk of specific microvascular complications in the medium term, then the findings in this study support proposals for the revision of diagnostic criteria based on glucose-tolerance tests.
Similar articles
- Hyperglycaemia and diabetes mellitus.
Jarrett RJ, Keen H. Jarrett RJ, et al. Lancet. 1976 Nov 6;2(7993):1009-12. doi: 10.1016/s0140-6736(76)90844-8. Lancet. 1976. PMID: 62224 - Prevalence of retinopathy in people with diabetes, impaired glucose tolerance, and normal glucose tolerance.
Rajala U, Laakso M, Qiao Q, Keinänen-Kiukaanniemi S. Rajala U, et al. Diabetes Care. 1998 Oct;21(10):1664-9. doi: 10.2337/diacare.21.10.1664. Diabetes Care. 1998. PMID: 9773727 - Development of retinopathy and proteinuria in relation to plasma-glucose concentrations in Pima Indians.
Pettitt DJ, Knowler WC, Lisse JR, Bennett PH. Pettitt DJ, et al. Lancet. 1980 Nov 15;2(8203):1050-2. doi: 10.1016/s0140-6736(80)92274-6. Lancet. 1980. PMID: 6107679
Cited by
- Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes?
Perreault L, Færch K, Gregg EW. Perreault L, et al. Curr Diab Rep. 2017 Sep;17(9):77. doi: 10.1007/s11892-017-0899-7. Curr Diab Rep. 2017. PMID: 28766246 Review. - Examination of the fasting and 2-h plasma glucose in the light of impairment in beta-cell function: what does the epidemiological data tell us?
Doi SA, Ward GM. Doi SA, et al. Endocrine. 2015 Feb;48(1):170-8. doi: 10.1007/s12020-014-0284-0. Epub 2014 Jun 1. Endocrine. 2015. PMID: 24880620 - Diagnosing diabetes with glucose criteria: worshiping a false God.
Davidson MB. Davidson MB. Diabetes Care. 2011 Feb;34(2):524-6. doi: 10.2337/dc10-1689. Diabetes Care. 2011. PMID: 21270208 Free PMC article. No abstract available. - International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes.
International Expert Committee. International Expert Committee. Diabetes Care. 2009 Jul;32(7):1327-34. doi: 10.2337/dc09-9033. Epub 2009 Jun 5. Diabetes Care. 2009. PMID: 19502545 Free PMC article. No abstract available. - Diagnostic criteria for diabetes revisited: making use of combined criteria.
Parappil A, Doi SA, Al-Shoumer KA. Parappil A, et al. BMC Endocr Disord. 2002;2(1):1. doi: 10.1186/1472-6823-2-1. BMC Endocr Disord. 2002. PMID: 11866866 Free PMC article.