Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis - PubMed (original) (raw)
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
J A Kreidberg et al. Development. 1996 Nov.
Abstract
A mutation was targeted to the murine alpha3 integrin gene. Homozygous mutant mice survived to birth, but died during the neonatal period. The mutation caused abnormal kidney and lung development. Mutant kidneys displayed decreased branching of the medullary collecting ducts, although the number of nephrons was not altered. Proximal tubules exhibited two distinct subsets of abnormalities, with the epithelial cells either containing excess lysosomes or becoming microcystic. In addition, glomerular development was markedly affected. In mutant kidneys, the extent of branching of glomerular capillary loops was decreased, with capillary lumina being wider than normal. The glomerular basement membrane was disorganized and glomerular podocytes were unable to form mature foot processes. Branching of the bronchi in lungs of mutant mice was also decreased and the large bronchi extended to the periphery. These results indicate a role for integrin receptors in basement membrane organization and branching morphogenesis.
Similar articles
- Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination.
Raghavan S, Bauer C, Mundschau G, Li Q, Fuchs E. Raghavan S, et al. J Cell Biol. 2000 Sep 4;150(5):1149-60. doi: 10.1083/jcb.150.5.1149. J Cell Biol. 2000. PMID: 10974002 Free PMC article. - Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development.
Zent R, Bush KT, Pohl ML, Quaranta V, Koshikawa N, Wang Z, Kreidberg JA, Sakurai H, Stuart RO, Nigám SK. Zent R, et al. Dev Biol. 2001 Oct 15;238(2):289-302. doi: 10.1006/dbio.2001.0391. Dev Biol. 2001. PMID: 11784011 - Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.
De Arcangelis A, Mark M, Kreidberg J, Sorokin L, Georges-Labouesse E. De Arcangelis A, et al. Development. 1999 Sep;126(17):3957-68. doi: 10.1242/dev.126.17.3957. Development. 1999. PMID: 10433923 - Dystroglycan and laminins: glycoconjugates involved in branching epithelial morphogenesis.
Durbeej M, Ekblom P. Durbeej M, et al. Exp Lung Res. 1997 Mar-Apr;23(2):109-18. doi: 10.3109/01902149709074024. Exp Lung Res. 1997. PMID: 9088921 Review. - Beta1-integrins and glomerular injury.
Kagami S, Kondo S. Kagami S, et al. J Med Invest. 2004 Feb;51(1-2):1-13. doi: 10.2152/jmi.51.1. J Med Invest. 2004. PMID: 15000250 Review.
Cited by
- Keratinocyte Integrin α3β1 Promotes Efficient Healing of Wound Epidermis.
Dhulipalla S, Duarte GA, Wu L, DiPersio MR, Lamar JM, DiPersio CM, Longmate WM. Dhulipalla S, et al. JID Innov. 2024 Aug 29;5(1):100310. doi: 10.1016/j.xjidi.2024.100310. eCollection 2025 Jan. JID Innov. 2024. PMID: 39385750 Free PMC article. - Roles for epithelial integrin α3β1 in regulation of the microenvironment during normal and pathological tissue remodeling.
Miskin RP, DiPersio CM. Miskin RP, et al. Am J Physiol Cell Physiol. 2024 May 1;326(5):C1308-C1319. doi: 10.1152/ajpcell.00128.2024. Epub 2024 Mar 18. Am J Physiol Cell Physiol. 2024. PMID: 38497112 Review. - The Role of α3β1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment.
Bosquetti B, Santana AA, Gregório PC, Cunha RSD, Miniskiskosky G, Budag J, Franco CRC, Ramos EAS, Barreto FC, Stinghen AEM. Bosquetti B, et al. Toxins (Basel). 2023 Dec 14;15(12):700. doi: 10.3390/toxins15120700. Toxins (Basel). 2023. PMID: 38133204 Free PMC article. - _N_-linked glycans: an underappreciated key determinant of T cell development, activation, and function.
Abdelbary M, Nolz JC. Abdelbary M, et al. Immunometabolism (Cobham). 2023 Nov 21;5(4):e00035. doi: 10.1097/IN9.0000000000000035. eCollection 2023 Oct. Immunometabolism (Cobham). 2023. PMID: 38027254 Free PMC article. Review. - Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Liu L, Hu H, Wu J, Koleske AJ, Chen H, Wang N, Yu K, Wu Y, Xiao X, Zhang Q. Liu L, et al. CNS Neurosci Ther. 2024 Apr;30(4):e14498. doi: 10.1111/cns.14498. Epub 2023 Oct 23. CNS Neurosci Ther. 2024. PMID: 37867481 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases