Late complications of immune deviation therapy in a nonhuman primate - PubMed (original) (raw)
Late complications of immune deviation therapy in a nonhuman primate
C P Genain et al. Science. 1996.
Abstract
The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (TH1) to a TH2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.
Comment in
- Complexities in the treatment of autoimmune disease.
McFarland HF. McFarland HF. Science. 1996 Dec 20;274(5295):2037-8. doi: 10.1126/science.274.5295.2037. Science. 1996. PMID: 8984662 No abstract available.
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