Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity - PubMed (original) (raw)

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.

Song F, Kovac V, Mohammadi B, Littau JL, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann JE, Damme M, Tschirner SK, Lichtenthaler SF, Ricklefs FL, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik MS, Sepulveda-Falla D, Matschke J, Šmid LM, Bresjanac M, Andreoletti O, Krasemann S, Foliaki ST, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh CL, Glatzel M, Curin Serbec V, Altmeppen HC. Song F, et al. Acta Neuropathol. 2024 Jul 9;148(1):2. doi: 10.1007/s00401-024-02763-5. Acta Neuropathol. 2024. PMID: 38980441 Free PMC article.

Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents.

Marín-Moreno A, Benestad SL, Barrio T, Pirisinu L, Espinosa JC, Tran L, Huor A, Di Bari MA, Eraña H, Maddison BC, D'Agostino C, Fernández-Borges N, Canoyra S, Jerez-Garrido N, Castilla J, Spiropoulos J, Bishop K, Gough KC, Nonno R, Våge J, Andréoletti O, Torres JM. Marín-Moreno A, et al. Vet Res. 2024 May 15;55(1):62. doi: 10.1186/s13567-024-01320-y. Vet Res. 2024. PMID: 38750594 Free PMC article.