Interleukin 6 in intact and injured mouse peripheral nerves - PubMed (original) (raw)

Interleukin 6 in intact and injured mouse peripheral nerves

F Reichert et al. Eur J Neurosci. 1996 Mar.

Abstract

The multifunctional cytokine interleukin 6 (IL-6) has direct growth, survival and differentiation effects on peripheral and central neurons. Furthermore, it can modulate the production by non-neuronal cells of other cytokines and growth factors, and thereby affect nerve cells indirectly. We have studied IL-6 expression and production in intact and injured peripheral nerves of C57/BL/6NHSD mice, which display the normal rapid progression of Wallerian degeneration. The IL-6 mRNA was detected in nerves degenerating in vitro or in vivo, but not in intact nerves. In vitro- and in vivo-degenerating nerve segments and neuroma nerve segments synthesized and secreted IL-6. The onset of IL-6 production was rapid and prolonged. It was detected as early as 2 h after injury and persisted for the entire period of 21 days tested after the injury. Of the non-neuronal cells that reside in intact and injured nerves, macrophages and fibroblasts were the major contributors to IL-6 production. We also studied IL-6 production in intact and injured nerves of mutant C57BL/6-WLD/OLA/NHSD mice, which display very slow progression of Wallerian degeneration. Injured nerves of C57BL/6-WLD/OLA/NHSD mice produced significantly lower amounts of IL-6 than did rapidly degenerating nerves of C57/BL/6NHSD mice.

PubMed Disclaimer

Similar articles

• The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta.
  Shamash S, Reichert F, Rotshenker S. Shamash S, et al. J Neurosci. 2002 Apr 15;22(8):3052-60. doi: 10.1523/JNEUROSCI.22-08-03052.2002. J Neurosci. 2002. PMID: 11943808 Free PMC article.
• Fibroblasts that reside in mouse and frog injured peripheral nerves produce apolipoproteins.
  Saada A, Dunaevsky-Hutt A, Aamar A, Reichert F, Rotshenker S. Saada A, et al. J Neurochem. 1995 May;64(5):1996-2003. doi: 10.1046/j.1471-4159.1995.64051996.x. J Neurochem. 1995. PMID: 7722485
• The cytokine network of wallerian degeneration: IL-10 and GM-CSF.
  Be'eri H, Reichert F, Saada A, Rotshenker S. Be'eri H, et al. Eur J Neurosci. 1998 Aug;10(8):2707-13. Eur J Neurosci. 1998. PMID: 9767400
• Mechanisms of macrophage recruitment in Wallerian degeneration.
  Brück W, Brück Y, Maruschak B, Friede RL. Brück W, et al. Acta Neuropathol. 1995;89(4):363-7. doi: 10.1007/BF00309630. Acta Neuropathol. 1995. PMID: 7610768

Cited by

• Sustained Release of Tacrolimus Embedded in a Mixed Thermosensitive Hydrogel for Improving Functional Recovery of Injured Peripheral Nerves in Extremities.
  Wang AYL, Chen KH, Lin HC, Loh CYY, Chang YC, Aviña AE, Lee CM, Chu IM, Wei FC. Wang AYL, et al. Pharmaceutics. 2023 Feb 3;15(2):508. doi: 10.3390/pharmaceutics15020508. Pharmaceutics. 2023. PMID: 36839830 Free PMC article.
• Wallerian degeneration in C57BL/6J and A/J mice: differences in time course of neurofilament and myelin breakdown, macrophage recruitment and iNOS expression.
  de la Hoz CL, Oliveira AL, Queiroz Lde S, Langone F. de la Hoz CL, et al. J Anat. 2003 Dec;203(6):567-78. doi: 10.1046/j.1469-7580.2003.00248.x. J Anat. 2003. PMID: 14686692 Free PMC article.
• Sildenafil attenuates inflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage.
  Garcia LA, Hlaing SM, Gutierrez RA, Sanchez MD, Kovanecz I, Artaza JN, Ferrini MG. Garcia LA, et al. Int J Mol Sci. 2014 Sep 26;15(10):17204-20. doi: 10.3390/ijms151017204. Int J Mol Sci. 2014. PMID: 25264738 Free PMC article.
• The Neuroimmunology of Guillain-Barré Syndrome and the Potential Role of an Aging Immune System.
  Hagen KM, Ousman SS. Hagen KM, et al. Front Aging Neurosci. 2021 Jan 13;12:613628. doi: 10.3389/fnagi.2020.613628. eCollection 2020. Front Aging Neurosci. 2021. PMID: 33584245 Free PMC article. Review.
• Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2-IL-6 axis.
  Lee HJ, Kim HJ, Ko JH, Oh JY. Lee HJ, et al. J Neuroinflammation. 2023 Feb 7;20(1):27. doi: 10.1186/s12974-023-02710-3. J Neuroinflammation. 2023. PMID: 36750851 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley