Morphology, function and pathology of follicular dendritic cells - PubMed (original) (raw)
Review
Morphology, function and pathology of follicular dendritic cells
Y Imal et al. Pathol Int. 1996 Nov.
Abstract
The precise ultrastructural morphology and functions in reactive conditions of lymphoid follicles (LF) and dendritic cells, including follicular dendritic cells (FDC) are reviewed; as well as the pathognomonic role of FDC in some disease conditions and finally, the cellular origin of FDC. In reactive conditions, FDC in each of the five follicular zones have distinct ultrastructural features, reflecting the different three-dimensional structures and functions of these zones. The FDC framework may be supported by some characteristic factors, including desmosome-like junctions between FDC and the expression of fibronectin and laminin receptors and caldesmon on FDC. FDC, especially in the light zone, express various cytokine receptors, but produce only one cytokine, TGF-beta. The outer zone may not only be a cellular pathway in the LF, but may also provide a site for germinal center B cell proliferation, and the FDC-lymphocyte cluster is not the site of germinal center B cell division. In patients with auto-immune diseases, such as Hashimoto's thyroiditis and rheumatoid arthritis, FDC may be in a hyperfunctional state, whereas those in patients with immunosuppressive disorders, such as Kimura's disease and AIDS, may be in a dysfunctional state. FDC may be derived from fibroblastic reticulum cells in lymphatic tissues rather than in bone marrow cells. The data discussed in this review provide fascinating insight into the roles of FDC, which are intimately related to the migration, proliferation, cell selection and differentiation of B cells in secondary LF.
Similar articles
- [Follicular dendritic cells: phenotype, origin and functions].
Heinen E. Heinen E. Pathol Biol (Paris). 1995 Dec;43(10):848-57. Pathol Biol (Paris). 1995. PMID: 8786889 Review. French. - Direct cell/cell communication in the lymphoid germinal center: connexin43 gap junctions functionally couple follicular dendritic cells to each other and to B lymphocytes.
Krenacs T, van Dartel M, Lindhout E, Rosendaal M. Krenacs T, et al. Eur J Immunol. 1997 Jun;27(6):1489-97. doi: 10.1002/eji.1830270627. Eur J Immunol. 1997. PMID: 9209502 - Follicular dendritic cells in non-Hodgkin's lymphomas.
Petrasch S, Brittinger G, Wacker HH, Schmitz J, Kosco-Vilbois M. Petrasch S, et al. Leuk Lymphoma. 1994 Sep;15(1-2):33-43. doi: 10.3109/10428199409051675. Leuk Lymphoma. 1994. PMID: 7858501 Review. - Follicular dendritic cell dysfunction and disorganization of lymphoid structures in MRL/lpr mice.
Masuda A, Kasajima T. Masuda A, et al. Lab Invest. 1999 Jul;79(7):849-57. Lab Invest. 1999. PMID: 10418825
Cited by
- New tools for immunologists: models of lymph node function from cells to tissues.
Ozulumba T, Montalbine AN, Ortiz-Cárdenas JE, Pompano RR. Ozulumba T, et al. Front Immunol. 2023 May 10;14:1183286. doi: 10.3389/fimmu.2023.1183286. eCollection 2023. Front Immunol. 2023. PMID: 37234163 Free PMC article. Review. - New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ.
This S, Paidassi H. This S, et al. Front Immunol. 2022 Aug 22;13:942468. doi: 10.3389/fimmu.2022.942468. eCollection 2022. Front Immunol. 2022. PMID: 36072589 Free PMC article. Review. - Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1).
Gordon L, Mabbott N, Wells J, Kulik L, Juleff N, Charleston B, Perez-Martin E. Gordon L, et al. PLoS Pathog. 2022 May 5;18(5):e1009942. doi: 10.1371/journal.ppat.1009942. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35512014 Free PMC article. - Follicular dendritic cell sarcoma presenting as a thyroid mass: an unusual case report and literature review.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H. Zhang T, et al. J Int Med Res. 2020 Jun;48(6):300060520920433. doi: 10.1177/0300060520920433. J Int Med Res. 2020. PMID: 32589853 Free PMC article. Review. - Follicular dendritic cell sarcoma (FDCS) of urinary bladder with coexisting urothelial carcinoma-a case report.
Sun J, Wang C, Wang D, Wu J, Wang L, Zhao L, Teng L. Sun J, et al. BMC Urol. 2019 Sep 5;19(1):83. doi: 10.1186/s12894-019-0517-x. BMC Urol. 2019. PMID: 31488130 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources