Focal adhesions, contractility, and signaling - PubMed (original) (raw)
Review
Focal adhesions, contractility, and signaling
K Burridge et al. Annu Rev Cell Dev Biol. 1996.
Abstract
Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provided a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, in cells that are tightly adherent to the substrate, generates isometric tension. In turn, this leads to the bundling of actin filaments and the aggregation of integrins (extracellular matrix receptors) in the plane of the membrane. The aggregation of integrins activates the focal adhesion kinase and leads to the assembly of a multicomponent signaling complex.
Similar articles
- Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers.
Saoncella S, Echtermeyer F, Denhez F, Nowlen JK, Mosher DF, Robinson SD, Hynes RO, Goetinck PF. Saoncella S, et al. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2805-10. doi: 10.1073/pnas.96.6.2805. Proc Natl Acad Sci U S A. 1999. PMID: 10077592 Free PMC article. - Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions.
Pavalko FM, Chen NX, Turner CH, Burr DB, Atkinson S, Hsieh YF, Qiu J, Duncan RL. Pavalko FM, et al. Am J Physiol. 1998 Dec;275(6 Pt 1):C1591-601. Am J Physiol. 1998. PMID: 9843721 - The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.
Hotchin NA, Hall A. Hotchin NA, et al. J Cell Biol. 1995 Dec;131(6 Pt 2):1857-65. doi: 10.1083/jcb.131.6.1857. J Cell Biol. 1995. PMID: 8557752 Free PMC article. - Bidirectional signaling between the cytoskeleton and integrins.
Schoenwaelder SM, Burridge K. Schoenwaelder SM, et al. Curr Opin Cell Biol. 1999 Apr;11(2):274-86. doi: 10.1016/s0955-0674(99)80037-4. Curr Opin Cell Biol. 1999. PMID: 10209151 Review. - Syndecan proteoglycan contributions to cytoskeletal organization and contractility.
Okina E, Manon-Jensen T, Whiteford JR, Couchman JR. Okina E, et al. Scand J Med Sci Sports. 2009 Aug;19(4):479-89. doi: 10.1111/j.1600-0838.2009.00941.x. Epub 2009 Jun 15. Scand J Med Sci Sports. 2009. PMID: 19538537 Review.
Cited by
- Visualizing the Cell-Matrix Interactions and Cytoskeleton of Disseminated Tumor Cells.
Shibue T. Shibue T. Methods Mol Biol. 2024;2811:207-220. doi: 10.1007/978-1-0716-3882-8_16. Methods Mol Biol. 2024. PMID: 39037661 - Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review.
Al-Husinat L, Azzam S, Al Sharie S, Al Sharie AH, Battaglini D, Robba C, Marini JJ, Thornton LT, Cruz FF, Silva PL, Rocco PRM. Al-Husinat L, et al. Crit Care. 2024 May 15;28(1):165. doi: 10.1186/s13054-024-04942-y. Crit Care. 2024. PMID: 38750543 Free PMC article. Review. - Integrins as the pivotal regulators of cisplatin response in tumor cells.
Nasimi Shad A, Moghbeli M. Nasimi Shad A, et al. Cell Commun Signal. 2024 May 13;22(1):265. doi: 10.1186/s12964-024-01648-0. Cell Commun Signal. 2024. PMID: 38741195 Free PMC article. Review. - Integrating shear flow and trypsin treatment to assess cell adhesion strength.
Patel A, Bhavanam B, Keenan T, Maruthamuthu V. Patel A, et al. Biointerphases. 2023 Nov 1;18(6):061002. doi: 10.1116/6.0003028. Biointerphases. 2023. PMID: 38078793 - Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation.
Kumar A, Tanaka K, Schwartz MA. Kumar A, et al. bioRxiv [Preprint]. 2024 Apr 18:2023.11.22.568289. doi: 10.1101/2023.11.22.568289. bioRxiv. 2024. PMID: 38045367 Free PMC article. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources