Influenza virus neuraminidase activates latent transforming growth factor beta - PubMed (original) (raw)

Influenza virus neuraminidase activates latent transforming growth factor beta

S Schultz-Cherry et al. J Virol. 1996 Dec.

Abstract

Transforming growth factor beta (TGF-beta) is a family of proteins secreted by virtually all cells in a biologically inactive form. TGF-beta levels increase during many pathophysiological situations, including viral infection. The mechanism for increased TGF-beta activity during viral infection is not understood. We observed an increase in active TGF-beta levels within 1 day in mice infected with influenza virus. Further studies showed that the neuraminidase glycoprotein of influenza A and B viruses directly activates latent TGF-beta in vitro. There are sufficient levels of TGF-beta activated by virus to induce apoptosis in cells. In addition, influenza virus-induced apoptosis is partially inhibited by TGF-beta-specific antibodies. These novel findings suggest a potential role for activation of TGF-beta during the host response to influenza virus infection, specifically apoptosis. This is the first report showing direct activation of latent TGF-beta by a viral protein.

PubMed Disclaimer

Similar articles

• Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis.
  Carlson CM, Turpin EA, Moser LA, O'Brien KB, Cline TD, Jones JC, Tumpey TM, Katz JM, Kelley LA, Gauldie J, Schultz-Cherry S. Carlson CM, et al. PLoS Pathog. 2010 Oct 7;6(10):e1001136. doi: 10.1371/journal.ppat.1001136. PLoS Pathog. 2010. PMID: 20949074 Free PMC article.
• Influenza viral neuraminidase primes bacterial coinfection through TGF-β-mediated expression of host cell receptors.
  Li N, Ren A, Wang X, Fan X, Zhao Y, Gao GF, Cleary P, Wang B. Li N, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):238-43. doi: 10.1073/pnas.1414422112. Epub 2014 Dec 22. Proc Natl Acad Sci U S A. 2015. PMID: 25535343 Free PMC article.
• Dose-dependent changes in influenza virus-infected dendritic cells result in increased allogeneic T-cell proliferation at low, but not high, doses of virus.
  Oh S, McCaffery JM, Eichelberger MC. Oh S, et al. J Virol. 2000 Jun;74(12):5460-9. doi: 10.1128/jvi.74.12.5460-5469.2000. J Virol. 2000. PMID: 10823850 Free PMC article.
• Inhibition of sialidase activity as a therapeutic approach.
  Glanz VY, Myasoedova VA, Grechko AV, Orekhov AN. Glanz VY, et al. Drug Des Devel Ther. 2018 Oct 10;12:3431-3437. doi: 10.2147/DDDT.S176220. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30349196 Free PMC article. Review.
• [The rapid detection kit based on neuraminidase activity of influenza virus].
  Shimizu H. Shimizu H. Nihon Rinsho. 2000 Nov;58(11):2234-7. Nihon Rinsho. 2000. PMID: 11225310 Review. Japanese.

Cited by

• Ex Pluribus Unum: The CD4 T Cell Response against Influenza A Virus.
  Finn CM, McKinstry KK. Finn CM, et al. Cells. 2024 Apr 5;13(7):639. doi: 10.3390/cells13070639. Cells. 2024. PMID: 38607077 Free PMC article. Review.
• Mathematical Modeling of the Lethal Synergism of Coinfecting Pathogens in Respiratory Viral Infections: A Review.
  Mochan E, Sego TJ. Mochan E, et al. Microorganisms. 2023 Dec 13;11(12):2974. doi: 10.3390/microorganisms11122974. Microorganisms. 2023. PMID: 38138118 Free PMC article. Review.
• Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections.
  Rasquel-Oliveira FS, Silva MDVD, Martelossi-Cebinelli G, Fattori V, Casagrande R, Verri WA Jr. Rasquel-Oliveira FS, et al. Molecules. 2023 Jun 27;28(13):5032. doi: 10.3390/molecules28135032. Molecules. 2023. PMID: 37446699 Free PMC article. Review.
• Microvascular significance of TGF-β axis activation in COVID-19.
  Arguinchona LM, Zagona-Prizio C, Joyce ME, Chan ED, Maloney JP. Arguinchona LM, et al. Front Cardiovasc Med. 2023 Jan 6;9:1054690. doi: 10.3389/fcvm.2022.1054690. eCollection 2022. Front Cardiovasc Med. 2023. PMID: 36684608 Free PMC article. Review.
• Inhibitors of the Sialidase NEU3 as Potential Therapeutics for Fibrosis.
  Karhadkar TR, Chen W, Pilling D, Gomer RH. Karhadkar TR, et al. Int J Mol Sci. 2022 Dec 23;24(1):239. doi: 10.3390/ijms24010239. Int J Mol Sci. 2022. PMID: 36613682 Free PMC article. Review.

References

1. 1. Nature. 1989 Mar 9;338(6211):158-60 - PubMed
2. 1. Virology. 1988 May;164(1):230-7 - PubMed
3. 1. J Virol. 1989 Aug;63(8):3453-8 - PubMed
4. 1. J Gen Virol. 1989 Nov;70 ( Pt 11):2887-95 - PubMed
5. 1. J Exp Med. 1990 Jul 1;172(1):121-9 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database